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1. (WO1998051293) USE OF BETULINIC ACID DERIVATIVES FOR THE TREATMENT AND PREVENTION OF MELANOMA
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/051293 International Application No.: PCT/US1998/007007
Publication Date: 19.11.1998 International Filing Date: 06.04.1998
Chapter 2 Demand Filed: 23.11.1998
IPC:
A61K 31/047 (2006.01) ,A61K 31/075 (2006.01) ,A61K 31/133 (2006.01) ,A61K 31/15 (2006.01) ,A61K 31/16 (2006.01) ,A61K 31/19 (2006.01) ,A61K 31/195 (2006.01) ,A61K 31/196 (2006.01) ,A61K 31/215 (2006.01) ,A61K 31/216 (2006.01) ,A61K 31/56 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
047
having two or more hydroxy groups, e.g. sorbitol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
075
Ethers or acetals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
133
having hydroxy groups, e.g. sphingosine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
15
Oximes (CN-O-); Hydrazines (N-N); Hydrazones (N-N)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
196
the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
216
of acids having aromatic rings, e.g. benactizyne, clofibrate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS[US/US]; 352 Administration Building 506 South Wright Street Urbana, IL 61801, US
Inventors: PEZZUTO, John, M.; US
DASGUPTA, Tapas, K.; US
KIM, Darrick, S., H., L.; US
Agent: NAPOLI, James, J.; Marshall, O'Toole, Gerstein, Murray & Borun Suite 6300 233 South Wacker Drive Chicago, IL 60606, US
Priority Data:
08/858,01116.05.1997US
Title (EN) USE OF BETULINIC ACID DERIVATIVES FOR THE TREATMENT AND PREVENTION OF MELANOMA
(FR) UTILISATION DE DERIVES DE L'ACIDE BETULINIQUE POUR LE TRAITEMENT ET LA PREVENTION DES MELANOMES
Abstract:
(EN) A composition and method of preventing or inhibiting tumor growth, and of treating malignant melanoma, without toxic side effects are disclosed. Betulinic acid or a betulinic acid derivative is the active compound of the composition, which is topically applied to the situs of tumor.
(FR) L'invention porte sur des compositions et méthodes de prévention ou inhibition de la croissance tumorale et de traitement des mélanomes malins ne provoquant pas d'effets secondaires toxiques. L'acide bétulinique ou ses dérivés est le principe actif de ces compositions qui s'appliquent localement sur le site de la tumeur.
Designated States: CA, JP
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)