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1. (WO1998051279) METHOD OF MAKING MICROENCAPSULATED DNA FOR VACCINATION AND GENE THERAPY

Pub. No.:    WO/1998/051279    International Application No.:    PCT/GB1998/001403
Publication Date: Fri Nov 20 00:59:59 CET 1998 International Filing Date: Sat May 16 01:59:59 CEST 1998
IPC: A61K 9/00
A61K 9/16
A61K 39/15
A61K 39/165
A61K 48/00
C12N 15/88
Applicants: MICROBIOLOGICAL RESEARCH AUTHORITY
FARRAR, Graham, Henry
JONES, David, Hugh
CLEGG, James, Christopher, Stephen
Inventors: FARRAR, Graham, Henry
JONES, David, Hugh
CLEGG, James, Christopher, Stephen
Title: METHOD OF MAKING MICROENCAPSULATED DNA FOR VACCINATION AND GENE THERAPY
Abstract:
A method of making a microparticle that contains DNA coding for a polypeptide is described in which a solvent extraction method is used and solvent extraction takes place at elevated temperature. Oral administration of the microparticle leads to its expression. DNA coding for an immunogen is for stimulating antibody formation in a recipient and DNA coding for a non-immunogenic polypeptide is for gene therapy applications. DNA is incorporated into the microparticle without destruction of its function.