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1. (WO1998051244) INTRAUTERINE CHEMICAL NECROSING METHOD, COMPOSITION, AND APPARATUS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051244 International Application No.: PCT/US1998/009560
Publication Date: 19.11.1998 International Filing Date: 11.05.1998
Chapter 2 Demand Filed: 07.12.1998
IPC:
A61K 9/00 (2006.01) ,A61K 47/36 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
Applicants:
NEUWIRTH, Robert, S. [US/US]; US
Inventors:
NEUWIRTH, Robert, S.; US
Agent:
BIRDE, Patrick, J. ; Kenyon & Kenyon One Broadway New York, NY 10004, US
Priority Data:
08/854,60412.05.1997US
Title (EN) INTRAUTERINE CHEMICAL NECROSING METHOD, COMPOSITION, AND APPARATUS
(FR) METHODE, COMPOSITION ET DISPOSITIF DE NECROSE CHIMIQUE INTRA-UTERINE
Abstract:
(EN) A method and composition for effecting chemical necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by delivering a caustic tissue necrosing composition, e.g., a silver nitrate and dextran paste, to the tissue to be necrosed and allowing the paste to remain in contact with the target tissue for a period of time sufficient to chemically necrose substantially the entirety of the tissue lining, and then contacting the caustic composition with a deactivating agent, e.g., an aqueous sodium chloride solution, thereby rendering the caustic composition non-caustic, and then rinsing the cavity. Compositions and methods for delivering medicaments are also disclosed.
(FR) L'invention concerne une méthode et une composition qui permettent de nécroser chimiquement le revêtement tissulaire d'une cavité corporelle d'un mammifère, notamment l'endomètre utérin. Selon la méthode, on administre au tissu à nécroser une composition nécrosante caustique pour les tissus, telle qu'une pâte à base de nitrate d'argent et de dextrane, et on laisse ladite pâte en contact avec le tissu cible pendant une durée suffisante pour nécroser chimiquement sensiblement la totalité du revêtement tissulaire; puis on met en contact la composition caustique avec un agent de désactivation, tel qu'une solution aqueuse de chlorure de sodium, ce qui rend la composition non caustique, et on rince la cavité. L'invention concerne également des compositions et des méthodes qui permettent d'administrer des médicaments.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXPA/a/1999/010446EP1006964RU02246954JP2002500644 CA2289462AU1998073785