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1. (WO1998051236) ARTIFICIAL GUT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/051236 International Application No.: PCT/US1998/010140
Publication Date: 19.11.1998 International Filing Date: 13.05.1998
Chapter 2 Demand Filed: 10.12.1998
IPC:
A61F 2/02 (2006.01) ,A61L 27/38 (2006.01) ,A61M 1/16 (2006.01) ,A61M 1/34 (2006.01) ,G09B 23/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02
Prostheses implantable into the body
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
36
containing ingredients of undetermined constitution or reaction products thereof
38
Animal cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1
Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
14
Dialysis systems; Artificial kidneys; Blood oxygenators
16
with membranes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1
Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
34
Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration, diafiltration
G PHYSICS
09
EDUCATING; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
B
EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
23
Models for scientific, medical, or mathematical purposes, e.g. full-sized device for demonstration purposes
28
for medicine
Applicants:
CEDARS-SINAI MEDICAL CENTER [US/US]; 8700 Beverly Boulevard Los Angeles, CA 90048, US
Inventors:
ROZGA, Jacek; US
DEMETRIOU, Achilles, A.; US
Agent:
KORDICH, Donald, C. ; Pretty, Schroeder & Poplawski 444 South Flower Street Los Angeles, CA 90071, US
Priority Data:
08/856,52214.05.1997US
Title (EN) ARTIFICIAL GUT
(FR) INTESTIN ARTIFICIEL
Abstract:
(EN) An artificial gut (100) comprises a first hollow fiber (203) having an inner surface (215) that is lined with at least a portion of a layer of one or more of a plurality of biological components (205) that typically line a mammalian gut. Further, a second hollow fiber (201) is adjacent the first hollow fiber. The layer of one or more of the plurality of biological components can consist essentially of enterocytes. The enterocyte-lined inner surface is perfused with a feeding solution containing nutrients, and the enterocytes absorb, process, and transport the nutrients across the wall of the first hollow fiber. The nutrients eventually diffuse into the second hollow fiber. A perfusate selected from the group consisting of culture medium, blood, and plasma, can perfuse an inner surface of the second hollow fiber, whereby the perfusate is nourished by the nutrients.
(FR) La présente invention concerne un intestin (100) artificiel comprenant une première fibre (203) creuse dotée d'une surface interne (215) tapissée d'au moins une partie d'une couche constituée d'un ou plusieurs d'une pluralité de constituants biologiques (205) recouvrant généralement l'intestin d'un mammifère. En outre, une seconde fibre (201) creuse est adjacente à la première fibre creuse. La couche constituée d'un ou plusieurs de la pluralité des constituants biologiques (205) comprend essentiellement des entérocytes. La surface interne tapissée d'entérocytes est perfusée par une solution d'alimentation contenant des éléments nutritifs et les entérocytes absorbent, traitent et transportent les éléments nutritifs à travers la paroi de la première fibre creuse. Les éléments nutritifs se diffusent éventuellement dans la seconde fibre creuse. Un perfusat sélectionné dans le groupe constitué par un milieu de culture, du sang et du plasma peut perfuser une surface interne de la seconde fibre creuse pendant que les éléments nutritifs alimentent ledit perfusat.
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Designated States: JP
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0984740JP2001525705