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1. (WO1998050575) METHOD AND APPARATUS FOR PREPARATION OF CHIRAL BETA AMINO ACIDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050575 International Application No.: PCT/US1998/007628
Publication Date: 12.11.1998 International Filing Date: 22.04.1998
Chapter 2 Demand Filed: 24.11.1998
IPC:
C12M 1/40 (2006.01) ,C12P 13/04 (2006.01) ,C12P 41/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
40
Apparatus specially designed for the use of free, immobilised, or carrier-bound enzymes, e.g. apparatus containing a fluidised bed of immobilised enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13
Preparation of nitrogen-containing organic compounds
04
Alpha- or beta-amino acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41
Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture
Applicants:
G.D. SEARLE & CO. [US/US]; Corporate Patent Dept. P.O. Box 5110 Chicago, IL 60680-5110, US (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
LANDIS, Brian, H. [US/US]; US (UsOnly)
NG, John, S. [US/US]; US (UsOnly)
TOPAI, Ravinda, S. [IN/US]; US (UsOnly)
YONAN, Edward, E. [US/US]; US (UsOnly)
WANG, Ping, T. [US/US]; US (UsOnly)
Inventors:
LANDIS, Brian, H.; US
NG, John, S.; US
TOPAI, Ravinda, S.; US
YONAN, Edward, E.; US
WANG, Ping, T.; US
Agent:
KOVACEVIC, Cynthia, S. ; G.D. Searle & Co. Corporate Patent Dept. P.O. Box 5110 Chicago, IL 60680-5110, US
Dr. Hans Chr. BEIL; Adelonstrasse 58 Postfach 80 01 40 D-65901 Frankfurt am Main, DE
Priority Data:
60/045,45401.05.1997US
Title (EN) METHOD AND APPARATUS FOR PREPARATION OF CHIRAL BETA AMINO ACIDS
(FR) PROCEDE ET APPAREIL DE PREPARATION DE BETA AMINO-ACIDES CHIRAUX
Abstract:
(EN) A method for preparing a chiral beta amino acid or its corresponding esters which comprises contacting a racemic beta amino acid, an acyl donor and Penicillin G acylase enzyme under conditions appropriate to stereoselectively acylate one enantiomer of the racemic beta amino acid to its corresponding N-acylated derivative whereby the opposite enantiomer of the beta amino acid is retained in enantiomerically enriched form.
(FR) L'invention concerne un procédé permettant de préparer un bêta amino-acide chiral ou ses esters correspondant, lequel procédé consiste à mettre en contact un bêta amino-acide racémique, un donneur acyle et une acylase de pénicilline G dans des conditions appropriées pour acyler stéréosélectivement un énantiomère du bêta amino-acide racémique de manière à obtenir le dérivé N-acylé correspondant, l'énantiomère inverse du bêta amino-acide étant retenu sous une forme enrichie énantiomériquement.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0979303JP2001523969 CA2287171AU1998073591