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1. (WO1998050567) REAGENTS AND METHODS USEFUL FOR DETECTING DISEASES OF THE PROSTATE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/050567 International Application No.: PCT/US1998/008930
Publication Date: 12.11.1998 International Filing Date: 01.05.1998
Chapter 2 Demand Filed: 04.12.1998
IPC:
A61K 38/00 (2006.01) ,C07K 16/30 (2006.01) ,C12Q 1/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: ABBOTT LABORATORIES[US/US]; 100 Abbott Park Road Abbott Park, IL 60064-3500, US
Inventors: BILLING-MEDEL, Patricia, A.; US
COHEN, Maurice; US
COLPITTS, Tracey, L.; US
FRIEDMAN, Paula, N.; US
GORDON, Julian; US
GRANADOS, Edward, N.; US
HODGES, Steven, C.; US
KLASS, Michael, R.; US
KRATOCHVIL, Jon, D.; US
ROBERTS-RAPP, Lisa; US
RUSSELL, John, C.; US
STROUPE, Stephen, D.; US
Agent: WEINSTOCK, Steven, F.; Abbott Laboratories D-377/AP6D 100 Abbott Park Road Abbott Park, IL 60064-3500 , US
Priority Data:
08/850,71302.05.1997US
Title (EN) REAGENTS AND METHODS USEFUL FOR DETECTING DISEASES OF THE PROSTATE
(FR) REACTIFS ET PROCEDES POUR DETECTER LES MALADIES DE LA PROSTATE
Abstract:
(EN) A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS108 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, $i(in vivo) imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS108-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS108 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.
(FR) L'invention concerne une série de séquences d'ADNc contiguës et partiellement chevauchantes et des polypeptides codés par lesdites séquences; ces polypeptides ont la désignation PS 108 et sont transcrits à partir du tissu de prostate. Les séquences en question sont utiles pour les opérations suivantes : détection, diagnostic, stadification, contrôle, pronostic, imagerie $i(in vivo), prévention ou traitement, ou détermination de la prédisposition d'un individu, pour les maladies et affections de la prostate, comme par exemple le cancer de la prostate. L'invention concerne aussi des anticorps à liaison spécifique avec une protéine ou un polypeptide à codage PS 108 ainsi que des agonistes ou des inhibiteurs empêchant l'action du polypeptide PS 108 spécifique du tissu, les molécules en question étant utiles pour le traitement thérapeutique des maladies, tumeurs ou métastases de la prostate.
Designated States: CA, JP
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)