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1. (WO1998050561) REGULATING METABOLISM BY MODIFYING THE LEVEL OF TREHALOSE-6-PHOSPHATE BY INHIBITING ENDOGENOUS TREHALASE LEVELS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050561 International Application No.: PCT/EP1998/002788
Publication Date: 12.11.1998 International Filing Date: 04.05.1998
Chapter 2 Demand Filed: 30.11.1998
IPC:
C12N 9/24 (2006.01) ,C12N 15/82 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
24
acting on glycosyl compounds (3.2)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
82
for plant cells
Applicants:
MOGEN INTERNATIONAL N.V. [NL/NL]; Einsteinweg 97 NL-2333 CB Leiden, NL (AllExceptUS)
GODDIJN, Oscar, Johannes, Maria [NL/NL]; NL (UsOnly)
PEN, Jan [NL/NL]; NL (UsOnly)
SMEEKENS, Josephus, Christianus, Maria [NL/NL]; NL (UsOnly)
SMITS, Maria, Theresia [NL/NL]; NL (UsOnly)
Inventors:
GODDIJN, Oscar, Johannes, Maria; NL
PEN, Jan; NL
SMEEKENS, Josephus, Christianus, Maria; NL
SMITS, Maria, Theresia; NL
Agent:
VAN WEZENBEEK, L., A., C., M.; Mogen International N.V. Einsteinweg 97 NL-2333 CB Leiden, NL
Priority Data:
PCT/EP97/0249702.05.1997NL
Title (EN) REGULATING METABOLISM BY MODIFYING THE LEVEL OF TREHALOSE-6-PHOSPHATE BY INHIBITING ENDOGENOUS TREHALASE LEVELS
(FR) METABOLISME REGULATEUR MODIFIANT LE NIVEAU DE TREHALOSE-6-PHOSPHATE PAR INHIBITION DES NIVEAUX DE TREHALASE ENDOGENE
Abstract:
(EN) The invention lies in the field of regulation of carbon flow in the metabolism of the cell. It has been found that induction of a change in the intracellular availability of the saccharide trehalose-6-phosphate (T-6-P) induces modifications of the development and/or composition of cells, tissue and organs $i(in vivo). These changes can be induced by inhibiting the endogenous enzyme trehalase which is capable of hydrolysing trehalose into two glucose moieties.
(FR) L'invention a trait au domaine de la régulation du débit de carbone dans le métabolisme d'une cellule. On a trouvé que l'induction d'un changement dans la disponibilité intracellulaire du tréhalose-6-phosphate saccharidique (T-6-P) provoquait $i(in vivo) des modifications de développement et/ou de composition de cellules, tissus et organes. Ces changements peuvent être induits par inhibition de l'enzyme endogène tréhalase, laquelle est capable d'hydrolyser le tréhalose en deux fractions glucosiques.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
KR1020010012147IL132498EP0977870JP2001523110 CN1260001CA2288672
AU1998077644