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1. (WO1998050556) INTRACELLULAR PRODUCTION OF HEPATITIS C E1 AND E2 TRUNCATED POLYPEPTIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050556 International Application No.: PCT/US1998/009097
Publication Date: 12.11.1998 International Filing Date: 06.05.1998
Chapter 2 Demand Filed: 22.10.1998
IPC:
A61K 39/00 (2006.01) ,C07K 14/18 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
18
Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus
Applicants:
CHIRON CORPORATION [US/US]; 4560 Horton Street - R440 Emeryville, CA 94608, US
Inventors:
HOUGTON, Michael; US
CHOO, Qui-Lim; US
ABRIGNANI, Sergio; US
CHIEN, David; US
SELBY, Mark; US
GLAZER, Edward; US
Agent:
HARBIN, Alisa, A.; Chiron Corporation Intellectual Property - R440 P.O. Box 8097 Emeryville, CA 49662-8097 , US
Priority Data:
60/045,67506.05.1997US
Title (EN) INTRACELLULAR PRODUCTION OF HEPATITIS C E1 AND E2 TRUNCATED POLYPEPTIDES
(FR) PRODUCTION INTRACELLULAIRE DE POLYPEPTIDES E1 ET E2 TRONQUES DIRIGES CONTRE L'HEPATITE C
Abstract:
(EN) Methods for obtaining recombinantly produced, C-terminally truncated, E1 and E2 polypeptides from cell lysates are disclosed. The intracellularly expressed truncated molecules display improved biological properties as compared to their secreted counterparts.
(FR) On décrit des procédés qui permettent de produire des polypeptides E1 et E2 tronqués à leur extrémité C-terminale, obtenus par recombinaison à partir de lysats cellulaires. Les molécules tronquées exprimées au niveau intracellulaire présentent des propriétés biologiques améliorées par comparaison avec leurs homologues secrétées.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0980434JP2008195722JP2009232863JP2002504810 CA2288374AU1998074716