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1. (WO1998050545) HUMAN SMT-3 LIKE PROTEIN
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What is claimed is:
1. A substantially purified human SMT3-like protein comprising the amino acid sequence of SEQ ID NO: 1 or fragments thereof.
2. An isolated and purified polynucleotide sequence encoding the human SMT3-like protein of claim 1.
3. A polynucleotide sequence which hybridizes under stringent conditions to the polynucleotide sequence of claim 2.
4. A composition comprising the polynucleotide sequence of claim 2.
5. An isolated and purified polynucleotide sequence comprising SEQ ID NO:2 or variants thereof.
6. A polynucleotide sequence which is complementary to the polynucleotide sequence of claim 2 or variants thereof.
7. A composition comprising the polynucleotide sequence of claim 6.
8. An expression vector containing the polynucleotide sequence of claim 2.
9. A host cell containing the vector of claim 8.
10. A method for producing a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, or fragments thereof, the method comprising the steps of:
a) culturing the host cell of claim 9 under conditions suitable for the expression of the polypeptide; and
b) recovering the polypeptide from the host cell culture.
11. A pharmaceutical composition comprising a substantially purified human
SMT3-like protein having the amino acid sequence of SEQ ID NO: 1 in conjunction with a suitable pharmaceutical carrier.
12. A purified antibody which binds to the polypeptide of claim 1.
13. A purified agonist which modulates the activity of the polypeptide of claim 1.
14. A purified antagonist which decreases the effect of the polypeptide of claim 1.
15. A method for promoting DNA repair comprising administering to a subject in need of such treatment the pharmaceutical composition of claim 11.
16. A pharmaceutical composition comprising the antagonist of claim 14 in conjunction with a suitable pharmaceutical carrier.
17. A method for treating or preventing a cancer comprising administering to a subject in need of such treatment the pharmaceutical composition of claim 16.

18. A method for treating or preventing inflammation comprising administering to a subject in need of such treatment the pharmaceutical composition of claim 16.
19. A method for detecting a polynucleotide which encodes the human SMT3-like protein in a biological sample comprising the steps of:
a) hybridizing the polynucleotide of claim 6 to nucleic acid material of a biological sample, thereby forming a hybridization complex; and
b) detecting said hybridization complex, wherein the presence of said complex correlates with the presence of a polynucleotide encoding the human SMT3-like protein in said biological sample.