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1. (WO1998050544) RECOMBINANT FRAGMENTS OF THE HUMAN ACETYLCHOLINE RECEPTOR AND THEIR USE FOR TREATMENT OF MYASTHENIA GRAVIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050544 International Application No.: PCT/IL1998/000211
Publication Date: 12.11.1998 International Filing Date: 06.05.1998
Chapter 2 Demand Filed: 23.11.1998
IPC:
A61K 38/00 (2006.01) ,C07K 14/705 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
Applicants:
YEDA RESEARCH AND DEVELOPMENT CO. LTD. [IL/IL]; at the Weizmann Institute of Science P.O. Box 95 76100 Rehovot, IL (AllExceptUS)
FUCHS, Sara [IL/IL]; IL (UsOnly)
BARCHAN, Dora [IL/IL]; IL (UsOnly)
SOUROUJON, Miriam, C. [IL/IL]; IL (UsOnly)
Inventors:
FUCHS, Sara; IL
BARCHAN, Dora; IL
SOUROUJON, Miriam, C.; IL
Agent:
BEN-AMI, Paulina; Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science P.O. Box 95 76100 Rehovot, IL
Priority Data:
12079207.05.1997IL
Title (EN) RECOMBINANT FRAGMENTS OF THE HUMAN ACETYLCHOLINE RECEPTOR AND THEIR USE FOR TREATMENT OF MYASTHENIA GRAVIS
(FR) FRAGMENTS DE RECOMBINAISON DU RECEPTEUR D'ACETYLCHOLINE HUMAIN ET LEUR UTILISATION POUR TRAITER LA MYASTHENIE
Abstract:
(EN) Polypeptides capable of modulating the autoimmune response of an individual to human acetylcholine receptor (hAChR), more particularly polypeptides corresponding entirely or partially to the extracellular domain of hAChR $g(a)-subunit, are useful in the diagnosis and treatment of myasthenia gravis. Preferred polypeptides are polypeptides corresponding to amino acid residues 1-121 or 122-210 of the hAChR $g(a)-subunit sequence, and polypeptides corresponding to amino acid residues 1-121, 1-210 or 1-205 of the hAChR $g(a)-subunit sequence in which is inserted, between amino acid residues 58 and 59, a sequence of 25 amino acid residues encoded by the p3A exon of the hAChR $g(a)-subunit gene, and fragments, analogs, fused, soluble and denatured forms thereof. DNA molecules encoding said polypeptides are also provided.
(FR) Polypeptides capables de moduler la réaction auto-immune d'un individu au récepteur d'acétylcholine humain (hAChR), plus particulièrement, polypeptides correspondant, en totalité ou en partie, au domaine extracellulaire d'une sous-unité $g(a) de hAChR et qui sont utiles pour le diagnostic ou le traitement de la myasthénie. Les polypeptides préférés sont des polypeptides correspondant aux résidus aminoacides 1-121 ou 122-210 de la séquence de la sous-unité $g(a) de hAChR, et des polypeptides correspondant aux résidus aminoacides 1-121 ou 1-205 de la séquence de sous-unité $g(a) de hAChR dans laquelle est insérée, entre les résidus aminoacides 58 et 59, une séquence de 25 résidus aminoacides codés par l'exon p3A du gène de la sous-unité $g(a) de hAChR, ainsi que leurs fragments, analogues ou leurs formes fusionnées, solubles et dénaturées. L'invention concerne également des molécules d'ADN codant lesdits polypeptides.
Designated States: AU, CA, HU, IL, JP, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL132697EP0980430US20070269865AU1998072308