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1. (WO1998050541) METHODS AND COMPOSITIONS TO FACILITATE D-LOOP FORMATION BY OLIGONUCLEOTIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050541 International Application No.: PCT/US1998/009443
Publication Date: 12.11.1998 International Filing Date: 08.05.1998
Chapter 2 Demand Filed: 04.12.1998
IPC:
C12N 15/11 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
Applicants:
EPOCH PHARMACEUTICALS, INC. [US/US]; Suite 100 12277 134th Court N.E. Redmond, WA 98052, US
Inventors:
MEYER, Rich, B., Jr.; US
GAMPER, Howard, B.; US
Agent:
BRENNAN, Sean, M. ; Morrison & Foerster LLP 755 Page Mill Road Palo Alto, CA 94304-1018, US
Priority Data:
09/074,62607.05.1998US
60/045,93608.05.1997US
Title (EN) METHODS AND COMPOSITIONS TO FACILITATE D-LOOP FORMATION BY OLIGONUCLEOTIDES
(FR) PROCEDES ET COMPOSITIONS FACILITANT LA FORMATION DE BOUCLE EN D PAR DES OLIGONUCLEOTIDES
Abstract:
(EN) Methods and compositions for efficient targeting and modification of target sequences in duplex DNA are provided, utilizing oligonucleotides or oligonucleotide compositions containing two domains. The first domain comprises an entity capable of recognizing a double-stranded DNA sequence. This can be a protein, peptide, antibiotic, minor groove binding agent or a nucleotide sequence capable of triplex formation. The second domain, which is covalently joined to the first, is capable of recognizing a single-stranded DNA sequence. This second domain will most often be complementary, in the Watson-Crick sense, to a target sequence in the double-stranded nucleic acid. The second domain can optionally carry one or more modifying groups, capable of causing a mutation, a pre-mutagenic lesion, or some other type of heritable change in the target sequence.
(FR) L'invention concerne des procédés et des compositions permettant un ciblage et une modification efficaces de séquences cibles dans un ADN double brin, ces procédés utilisant des oligonucléotides ou des compositions oligonucléotidiques contenant deux domaines. Le premier domaine comprend une entité capable de reconnaître une séquence d'ADN double brin, pouvant être une protéine, un peptide, un antibiotique, un agent de fixation au sillon mineur, ou une séquence nucléotidique capable de formation triplex. Le second domaine, lié par covalence au premier, est capable de reconnaître une séquence d'ADN double brin. Ce second domaine est souvent complémentaire, au sens de Watson et Crick, d'une séquence cible de l'acide nucléique double brin, et peut éventuellement être porteur d'un ou de plusieurs groupes modificateurs, capables de provoquer une mutation, une lésion prémutagène, ou tout autre type de changement héréditaire dans ladite séquence cible.
Designated States: JP
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)