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1. (WO1998050535) TRANSGENIC MICE EXPRESSING HIV-1 IN IMMUNE CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050535 International Application No.: PCT/CA1998/000434
Publication Date: 12.11.1998 International Filing Date: 05.05.1998
Chapter 2 Demand Filed: 03.12.1998
IPC:
C07K 14/16 (2006.01) ,C12N 15/85 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
15
Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155
Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
16
HIV-1
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
Applicants:
INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL [CA/CA]; 110 avenue des Pins Ouest Montréal, Québec H2W 1R7, CA (AllExceptUS)
JOLICOEUR, Paul [CA/CA]; CA (UsOnly)
HANNA, Zaher [CA/CA]; CA (UsOnly)
KAY, Denis, G. [CA/CA]; CA (UsOnly)
Inventors:
JOLICOEUR, Paul; CA
HANNA, Zaher; CA
KAY, Denis, G.; CA
Agent:
COTE, France; Swabey Ogilvy Renault Suite 1600 1981 McGill College Avenue Montréal, Québec H3A 2Y3, CA
Priority Data:
2,204,57206.05.1997CA
Title (EN) TRANSGENIC MICE EXPRESSING HIV-1 IN IMMUNE CELLS
(FR) SOURIS TRANSGENIQUES EXPRIMANT LE VIH-1 DANS LEURS CELLULES IMMUNITAIRES
Abstract:
(EN) The present invention relates to a transgenic mouse to serve as a small animal model of AIDS which comprises at least a DNA sequence coding for HIV-1 $i(nef) or an HIV-1 DNA genome essentially consisting in entire HIV-1 coding sequences under the control of the human CD4 gene promoter flanked by the enhancer of the mouse CD4 gene for expression in T cells and in cells of monocyte/microphage lineage. There is also provided a method to screen for therapeutic agents for the treatment of AIDS, which comprises the steps of: a) administering the therapeutic agent to the mouse of the present invention; and b) determining the effects of the therapeutic agent.
(FR) L'invention concerne une souris transgénique qui peut servir de petit modèle animal pour le sida et qui renferme au moins une séquence d'ADN codant pour la protéine $i(nef) du VIH-1 ou un génome d'ADN du VIH-1 constitué essentiellement de séquences codantes entières du VIH-1 sous le contrôle du promoteur du gène CD4 humain, flanqué de l'activateur du gène CD4 de la souris, lesdites séquences s'exprimant dans les lymphocytes T et dans les cellules de la lignée monocytes/microphages. L'invention concerne également une méthode permettant de cribler des agents thérapeutiques destinés au traitement du sida, qui comprend les étapes suivantes: a) on administre l'agent thérapeutique à la souris de la présente invention; et b) on détermine les effets dudit agent thérapeutique.
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Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US6184436CA2289236AU1998072029