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Pub. No.:    WO/1998/050533    International Application No.:    PCT/US1998/003200
Publication Date: 12.11.1998 International Filing Date: 06.05.1998
Chapter 2 Demand Filed:    01.12.1998    
C07D 307/22 (2006.01), C07D 307/32 (2006.01), C07D 307/83 (2006.01), C07D 307/86 (2006.01), C07D 309/30 (2006.01), C07D 405/12 (2006.01), C07D 407/12 (2006.01), C07D 409/12 (2006.01)
Applicants: SMITHKLINE BEECHAM CORPORATION [US/US]; One Franklin Plaza, Philadelphia, PA 19103 (US) (For All Designated States Except US).
SMITHKLINE BEECHAM PLC [GB/GB]; Great West Road, New Horizons Court, Brentford, Middlesex TW8 9BD (GB) (For All Designated States Except US).
GRIBBLE, Andrew, D. [GB/GB]; (GB) (For US Only).
FENWICK, Ashley, Edward [GB/GB]; (GB) (For US Only).
MARQUIS, Robert, W. [US/US]; (US) (For US Only).
VEBER, Daniel, F. [US/US]; (US) (For US Only).
WITHERINGTON, Jason [GB/GB]; (GB) (For US Only)
Inventors: GRIBBLE, Andrew, D.; (GB).
FENWICK, Ashley, Edward; (GB).
MARQUIS, Robert, W.; (US).
VEBER, Daniel, F.; (US).
Agent: McCARTHY, Mary, E.; SmithKline Beecham Corporation, Corporate Intellectual Property, UW2220, 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406-0939 (US)
Priority Data:
60/045,758 06.05.1997 US
Abstract: front page image
(EN)The invention relates to 3-hydroxy- and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hydroxy- or 3-keto-moiety is bonded to a tetrahydrothiophene, tetrahydrothiopyran, tetrahydrofuran or tetrahydropyran ring.
(FR)Cette invention se rapporte à des composés de leucine à substitution 3-hydroxy-cyclohétéro et 3-céto-cyclohétéro, qui constituent des inhibiteurs des cystéine-protéases, en particulier la cathépsine K, et qui sont utiles dans le traitement des maladies pour lesquelles l'inhibition de la déperdition osseuse constitue un facteur. La fraction 3-hydroxy ou 3-céto est liée à un cycle tétrahydrothiophène, tétrahydrothiopyranne, tétrahydrofuranne ou tétrahydropyranne.
Designated States: AL, AU, BA, BB, BG, BR, CA, CN, CZ, EE, GE, HU, ID, IL, IS, JP, KP, KR, LC, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, SL, TR, TT, UA, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)