Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO1998050533) PROTEASE INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050533 International Application No.: PCT/US1998/003200
Publication Date: 12.11.1998 International Filing Date: 06.05.1998
Chapter 2 Demand Filed: 01.12.1998
IPC:
C07D 307/22 (2006.01) ,C07D 307/32 (2006.01) ,C07D 307/83 (2006.01) ,C07D 307/86 (2006.01) ,C07D 309/30 (2006.01) ,C07D 405/12 (2006.01) ,C07D 407/12 (2006.01) ,C07D 409/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
18
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
22
Nitrogen atoms not forming part of a nitro radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
26
having one double bond between ring members or between a ring member and a non-ring member
30
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
32
Oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77
ortho- or peri-condensed with carbocyclic rings or ring systems
78
Benzo [b] furans; Hydrogenated benzo [b] furans
82
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
83
Oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77
ortho- or peri-condensed with carbocyclic rings or ring systems
78
Benzo [b] furans; Hydrogenated benzo [b] furans
86
with an oxygen atom directly attached in position 7
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
309
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
16
having one double bond between ring members or between a ring member and a non-ring member
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
30
Oxygen atoms, e.g. delta-lactones
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
407
Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
Applicants:
SMITHKLINE BEECHAM CORPORATION [US/US]; One Franklin Plaza Philadelphia, PA 19103, US (AllExceptUS)
SMITHKLINE BEECHAM PLC [GB/GB]; Great West Road New Horizons Court Brentford Middlesex TW8 9BD, GB (AllExceptUS)
GRIBBLE, Andrew, D. [GB/GB]; GB (UsOnly)
FENWICK, Ashley, Edward [GB/GB]; GB (UsOnly)
MARQUIS, Robert, W. [US/US]; US (UsOnly)
VEBER, Daniel, F. [US/US]; US (UsOnly)
WITHERINGTON, Jason [GB/GB]; GB (UsOnly)
Inventors:
GRIBBLE, Andrew, D.; GB
FENWICK, Ashley, Edward; GB
MARQUIS, Robert, W.; US
VEBER, Daniel, F.; US
WITHERINGTON, Jason; GB
Agent:
McCARTHY, Mary, E. ; SmithKline Beecham Corporation Corporate Intellectual Property, UW2220 709 Swedeland Road P.O. Box 1539 King of Prussia, PA 19406-0939, US
Priority Data:
60/045,75806.05.1997US
Title (EN) PROTEASE INHIBITORS
(FR) INHIBITEURS DE PROTEASES
Abstract:
(EN) The invention relates to 3-hydroxy- and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hydroxy- or 3-keto-moiety is bonded to a tetrahydrothiophene, tetrahydrothiopyran, tetrahydrofuran or tetrahydropyran ring.
(FR) Cette invention se rapporte à des composés de leucine à substitution 3-hydroxy-cyclohétéro et 3-céto-cyclohétéro, qui constituent des inhibiteurs des cystéine-protéases, en particulier la cathépsine K, et qui sont utiles dans le traitement des maladies pour lesquelles l'inhibition de la déperdition osseuse constitue un facteur. La fraction 3-hydroxy ou 3-céto est liée à un cycle tétrahydrothiophène, tétrahydrothiopyranne, tétrahydrofuranne ou tétrahydropyranne.
Designated States: AL, AU, BA, BB, BG, BR, CA, CN, CZ, EE, GE, HU, ID, IL, IS, JP, KP, KR, LC, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, SL, TR, TT, UA, US, UZ, VN, YU
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1999-3887NO19995434TR1999/02766MXPA/a/1999/010254KR1020010012256IL132088
EP1003846JP2001525804 CN1255161CA2288868NZ337889AU1998075625
MYPI 98001994