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1. (WO1998050533) PROTEASE INHIBITORS

Pub. No.:    WO/1998/050533    International Application No.:    PCT/US1998/003200
Publication Date: Fri Nov 13 00:59:59 CET 1998 International Filing Date: Thu May 07 01:59:59 CEST 1998
IPC: C07D 307/22
C07D 307/32
C07D 307/83
C07D 307/86
C07D 309/30
C07D 405/12
C07D 407/12
C07D 409/12
Applicants: SMITHKLINE BEECHAM CORPORATION
SMITHKLINE BEECHAM PLC
GRIBBLE, Andrew, D.
FENWICK, Ashley, Edward
MARQUIS, Robert, W.
VEBER, Daniel, F.
WITHERINGTON, Jason
Inventors: GRIBBLE, Andrew, D.
FENWICK, Ashley, Edward
MARQUIS, Robert, W.
VEBER, Daniel, F.
WITHERINGTON, Jason
Title: PROTEASE INHIBITORS
Abstract:
The invention relates to 3-hydroxy- and 3-keto-cyclohetero-substituted leucine compounds that are inhibitors of cysteine proteases, particularly cathepsin K, and are useful in the treatment of diseases in which inhibition of bone loss is a factor. The 3-hydroxy- or 3-keto-moiety is bonded to a tetrahydrothiophene, tetrahydrothiopyran, tetrahydrofuran or tetrahydropyran ring.