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Machine translation
1. (WO1998050527) METHOD FOR GENERATING ACTIVATED T-CELLS AND ANTIGEN-PULSED ANTIGEN-PRESENTING CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/050527 International Application No.: PCT/US1998/009288
Publication Date: 12.11.1998 International Filing Date: 07.05.1998
Chapter 2 Demand Filed: 08.12.1998
IPC:
A61K 39/00 (2006.01) ,C07K 14/47 (2006.01)
Applicants: AGRAWAL, Babita[IN/CA]; CA (UsOnly)
KRANTZ, Mark, J.[US/CA]; CA (UsOnly)
REDDISH, Mark, A.[US/CA]; CA (UsOnly)
LONGENECKER, B., Michael[US/CA]; CA (UsOnly)
BIOMIRA INC.[CA/CA]; Edmonton Research Park 2011-94 Street Edmonton, Alberta T6N 1H1, CA (AllExceptUS)
Inventors: AGRAWAL, Babita; CA
KRANTZ, Mark, J.; CA
REDDISH, Mark, A.; CA
LONGENECKER, B., Michael; CA
Agent: SAXE, Bernhard, D. ; Foley & Lardner Suite 500 3000 K Street, N.W. Washington, DC 20007-5109, US
Priority Data:
60/045,94908.05.1997US
Title (EN) METHOD FOR GENERATING ACTIVATED T-CELLS AND ANTIGEN-PULSED ANTIGEN-PRESENTING CELLS
(FR) PROCEDE DE GENERATION DE CELLULES T ACTIVEES ET DE CELLULES DE PRESENTATION D'ANTIGENE ET A IMPULSION ANTIGENIQUE
Abstract:
(EN) A method for generating a mixture of activated T-cells by combining a plurality of peripheral blood lymphocytes (PBLs) with an antigen-loaded liposome to produce antigen-loaded PBLs, and combining the antigen-loaded PBLs with a naive, anergic or memory T-cell, to produce an activated T-cell. Such activation is carried out $i(in vivo) or $i(in vitro). The antigen-loaded PBLs and activated T-cells, prepared according to the methods of invention, have use as cellular vaccines for treatment of cancer and viral diseases.
(FR) Cette invention se rapporte à un procédé de préparation d'un mélange de cellules T activées qui consiste à combiner une pluralité de lymphocytes circulants (PBL $i(peripheral blood lymphocytes)) à un liposome chargé d'antigène de façon à produire des PBL chargés d'antigènes, et à combiner ces PBL chargés d'antigènes avec une cellule T naïve, anergique ou à mémoire, de manière à produire une cellule T activée. Une telle activation s'effectue $i(in vivo) ou $i(in vitro). Les PBL chargés d'antigènes et les cellules T activées, préparées conformément au procédé de cette invention, s'avèrent utiles en tant que vaccins cellulaires destinés au traitement du cancer et des maladies virales.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)