Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1998050525) EMBRYONIC AND ADULT CNS STEM CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050525 International Application No.: PCT/US1998/009236
Publication Date: 12.11.1998 International Filing Date: 06.05.1998
Chapter 2 Demand Filed: 12.12.1998
IPC:
C12N 5/0793 (2010.01) ,G01N 33/50 (2006.01) ,G01N 33/94 (2006.01) ,A61K 35/12 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
079
Neural cells
0793
Neurons
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
94
involving narcotics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
Applicants:
NEURALSTEM BIOPHARMACEUTICALS [US/US]; 335 Paint Branch Drive College Park, MD 20742, US
Inventors:
JOHE, Karl, K.; US
Agent:
PICCIANO, Dante, J.; Bell, Boyd & Lloyd P.O. Box 1135 Chicago, IL 60690-1135, US
Priority Data:
08/919,58007.05.1997US
09/053,41401.04.1998US
Title (EN) EMBRYONIC AND ADULT CNS STEM CELLS
(FR) CELLULES SOUCHES PROVENANT DU SYSTEME NERVEUX CENTRAL ADULTE ET EMBRYONNAIRE
Abstract:
(EN) A homologous population of CNS multipotent precursor cells from mammalian embryonic neuroepithelial can be expanded in culture while maintaining their multipotential capacity. Chemically defined conditions can generate higher proportions of neurons, astrocytes or oligodendrocytes. In vitro cultures of region-specific, terminally differentiated, mature neurons derived from stem cell cultures are also described.
(FR) Procédé $i(in vitro) selon lequel une population homogène de cellules précurseurs pluripotentes du système nerveux central tirées de neuroépithélium embryonnaire mammalien peuvent être multipliées dans une culture tout en conservant leur capacité de pluripotence. Des conditions chimiquement définies permettent de produire des quantités beaucoup plus élevées de neurones, d'astrocytes ou d'oligodendrocytes. La présente invention concerne également des cultures $i(in vitro) de neurones matures à terminaison différenciée et spécifiques d'une région, dérivés de cultures de cellules souches.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0923640CA2259484AU1998072898