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1. (WO1998050523) METHODS FOR PRODUCING PHOSPHOLIPID METABOLITES IN YEAST
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050523 International Application No.: PCT/US1998/009233
Publication Date: 12.11.1998 International Filing Date: 06.05.1998
Chapter 2 Demand Filed: 20.11.1998
IPC:
C12P 7/18 (2006.01) ,C12P 7/64 (2006.01) ,C12P 9/00 (2006.01) ,C12P 13/00 (2006.01) ,C12P 19/30 (2006.01) ,C12Q 1/02 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
02
containing a hydroxy group
04
acyclic
18
polyhydric
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
64
Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
9
Preparation of organic compounds containing a metal or atom other than H, N, C, O, S, or halogen
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13
Preparation of nitrogen-containing organic compounds
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19
Preparation of compounds containing saccharide radicals
26
Preparation of nitrogen-containing carbohydrates
28
N-glycosides
30
Nucleotides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
Applicants:
CARNEGIE MELLON UNIVERSITY [US/US]; 5000 Forbes Avenue Pittsburgh, PA 15213, US
Inventors:
HENRY, Susan, A.; US
PATTON, Jana, L.; US
GRIAC, Peter; SK
KOHLWEIN, Sepp, D.; AT
Agent:
BUCKLES, Mary-Elizabeth ; Reed Smith Shaw & McClay P.O. Box 488 Pittsburgh, PA 15230, US
Priority Data:
08/852,45007.05.1997US
Title (EN) METHODS FOR PRODUCING PHOSPHOLIPID METABOLITES IN YEAST
(FR) PROCEDES DE PRODUCTION DE METABOLITES DE PHOSPHOLIPIDES DANS DES LEVURES
Abstract:
(EN) Methods are provided for increased and controlled production of choline and inositol, choline and inositol metabolites, and choline- and inositol-containing phospholipids in yeast, comprising the step of increasing phosphatidylcholine (PC) turnover in yeast (see the figure). Methods are also provided for detecting phospholipase D-mediated turnover of phosphatidylcholine $i(in vivo) in yeast, comprising an assay for choline excretion.
(FR) Procédés permettant une production accrue et régulée de choline et d'inositol, de métabolites de choline et d'inositol et de phospholipides contenant de la choline et de l'inositol dans des levures, qui comprennent une étape consistant à augmenter la rotation de la phosphatidylcholine (PC) dans des levures (voir la figure). Des procédés de détection de la rotation, induite par la phospholipase D, de la phosphatidylcholine $i(in vivo) dans des levures, ainsi qu'un dosage permettant la détection de l'excrétion de choline sont également décrits.
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Designated States: CA, JP
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0980423JP2000513586 CA2288313