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1. (WO1998050438) CHLORIDE LINKER FOR SOLID PHASE ORGANIC SYNTHESIS

Pub. No.:    WO/1998/050438    International Application No.:    PCT/US1998/009485
Publication Date: Fri Nov 13 00:59:59 CET 1998 International Filing Date: Sat May 09 01:59:59 CEST 1998
IPC: C08F 8/18
Applicants: SMITHKLINE BEECHAM CORPORATION
GARIGIPATI, Ravi, S.
Inventors: GARIGIPATI, Ravi, S.
Title: CHLORIDE LINKER FOR SOLID PHASE ORGANIC SYNTHESIS
Abstract:
This invention relates to a linker for use in solid phase synthesis, its preparation and methods of use. The linker consists essentially of an alkoxy substituted phenyl ring bearing an optionally substituted benzylic chloride. Synthetic components bearing a suitable nucleophile can displace the chlorine atom and form a covalent linkage to the support.