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1. (WO1998050433) HUMAN MONOCLONAL ANTIBODIES TO EPIDERMAL GROWTH FACTOR RECEPTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/050433 International Application No.: PCT/US1998/009160
Publication Date: 12.11.1998 International Filing Date: 05.05.1998
Chapter 2 Demand Filed: 01.12.1998
IPC:
A61K 38/00 (2006.01) ,C07K 16/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants: ABGENIX, INC.[US/US]; 7601 Dumbarton Circle Fremont, CA 94555, US
Inventors: JAKOBOVITS, Aya; US
YANG, Xiao-Dong; US
GALLO, Michael; US
JIA, Xiao-Chi; US
Agent: HALEY, James, F. ; Fish & Neave 1251 Avenue of the Americas New York, NY 10020, US
VOSSIUS & PARTNER; Siebertstrasse 4 81675 München, DE
Priority Data:
08/851,36205.05.1997US
Title (EN) HUMAN MONOCLONAL ANTIBODIES TO EPIDERMAL GROWTH FACTOR RECEPTOR
(FR) ANTICORPS MONOCLONAUX HUMAINS CONTRE LE RECEPTEUR DU FACTEUR DE CROISSANCE EPIDERMIQUE
Abstract:
(EN) In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
(FR) La présente invention concerne des anticorps monoclonaux entièrement humains contre le récepteur du facteur de croissance épidermique humain (EGF-r). Elle concerne également des séquences nucléotidiques codant et des séquences aminoacides comprenant des molécules d'immunoglobuline à chaînes lourdes et légères, notamment des séquences correspondant à des séquences de chaînes lourdes et légères contiguës, allant des régions déterminantes complémentaires CDR1 à CDR3. L'invention concerne d'autre part des hybridomes exprimant ces molécules d'immunoglobuline et ces anticorps monoclonaux.
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Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)