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1. (WO1998050432) RECOMBINANT ANTIBODY-ENZYME FUSION PROTEINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050432 International Application No.: PCT/US1998/008840
Publication Date: 12.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 26.10.1998
IPC:
A61K 47/48 (2006.01) ,C07K 16/30 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
Applicants:
BRISTOL-MYERS SQUIBB COMPANY [US/US]; 345 Park Avenue New York, NY 10154, US (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
SIEMERS, Nathan, O. [US/US]; US (UsOnly)
YARNOLD, Susan [US/US]; US (UsOnly)
SENTER, Peter, D. [US/US]; US (UsOnly)
Inventors:
SIEMERS, Nathan, O.; US
YARNOLD, Susan; US
SENTER, Peter, D.; US
Agent:
PARMELEE, Steven, W. ; Townsend and Townsend and Crew LLP 8th floor Two Embarcadero Center San Francisco, CA 94111, US
Priority Data:
09/070,63730.04.1998US
60/045,88807.05.1997US
Title (EN) RECOMBINANT ANTIBODY-ENZYME FUSION PROTEINS
(FR) PROTEINES FUSIONNEES D'ENZYMES ANTICORPS PRODUITES PAR RECOMBINAISON
Abstract:
(EN) The invention relates to recombinantly produced fusion polypeptides comprising antibody VH and VL sequences operatively linked to a $g(b)-lactamase for use in the delivery of cytotoxic drugs to tumor cells.
(FR) L'invention porte sur des polypeptides fusionnés produits par recombinaison comportant les séquences VH et VL d'anticorps fonctionnellement liées à une $g(b)-lactamase et servant à transférer des substances cytotoxiques à des cellules tumorales.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0986576JP2002510968 CA2289115AU1998072748