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Machine translation
1. (WO1998050430) HEMOGLOBIN MUTANTS WITH INCREASED SOLUBLE EXPRESSION AND/OR REDUCED NITRIC OXIDE SCAVENGING
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/050430 International Application No.: PCT/US1998/008861
Publication Date: 12.11.1998 International Filing Date: 01.05.1998
Chapter 2 Demand Filed: 11.09.1998
IPC:
A61K 38/00 (2006.01) ,C07K 14/805 (2006.01)
Applicants: WEICKERT, Michael, J.[US/US]; US (UsOnly)
GLASCOCK, Christopher, B.[US/US]; US (UsOnly)
MATHEWS, Antony, J.[NZ/US]; US (UsOnly)
LEMON, Douglas, D.[US/US]; US (UsOnly)
DOHERTY, Daniel, H.[US/US]; US (UsOnly)
OLSON, John, S.[US/US]; US (UsOnly)
SOMATOGEN, INC.[US/US]; Suite FD-1 2545 Central Avenue Boulder, CO 80301, US (AllExceptUS)
WILLIAM MARSH RICE UNIVERSITY[US/US]; Institute of Bioscience & Bioengineering 6100 South Main Houston, TX 77005, US (AllExceptUS)
Inventors: WEICKERT, Michael, J.; US
GLASCOCK, Christopher, B.; US
MATHEWS, Antony, J.; US
LEMON, Douglas, D.; US
DOHERTY, Daniel, H.; US
OLSON, John, S.; US
Agent: BROWN, Theresa, A.; Somatogen, Inc. Suite FD-1 2545 Central Avenue Boulder, CO 80301, US
MacGREGOR, Gordon; Eric Potter & Clarkson Park View House 58 The Ropewalk Nottingham NG1 5DD, GB
Priority Data:
60/045,36402.05.1997US
60/057,98605.09.1997US
Title (EN) HEMOGLOBIN MUTANTS WITH INCREASED SOLUBLE EXPRESSION AND/OR REDUCED NITRIC OXIDE SCAVENGING
(FR) MUTANTS D'HEMOGLOBINE AVEC EXPRESSION SOLUBLE ACCRUE ET/OU EVACUATION REDUITE D'OXYDE NITRIQUE
Abstract:
(EN) The invention relates to novel recombinant hemoglobins having reduced nitric oxide scavenging and/or increased high soluble expression. The invention further relates to methods of increasing the soluble expression of recombinant hemoglobin by adding exogenous hemin in molar excess of the heme binding sites of recombinant hemoglobin.
(FR) L'invention concerne de nouvelles hémoglobines recombinantes ayant une évacuation réduite d'oxyde nitrique et/ou une expression soluble accrue. L'invention concerne également des procédés permettant d'augmenter l'expression soluble de l'hémoglobine recombinante par ajout d'hémine exogène en excès molaire des sites de liaison hème de l'hémoglobine recombinante.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)