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1. (WO1998050419) 4-AZA-STEROIDS AS INHIBITORS OF TESTOSTERONE-5-ALPHA-REDUCTASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050419 International Application No.: PCT/CA1998/000438
Publication Date: 12.11.1998 International Filing Date: 06.05.1998
Chapter 2 Demand Filed: 26.11.1998
IPC:
C07J 71/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
71
Steroids in which the cyclopenta[a]hydrophenanthrene skeleton is condensed with a heterocyclic ring
Applicants:
NOVOPHARM LIMITED [CA/CA]; 30 Novopharm Court Scarborough, Ontario M1B 2K9, CA (AllExceptUS)
PAMIDI, Chenchaiah, Chinna [CA/CA]; CA (UsOnly)
JIA, Qi [CA/CA]; CA (UsOnly)
Inventors:
PAMIDI, Chenchaiah, Chinna; CA
JIA, Qi; CA
Agent:
RIDOUT & MAYBEE; 18th floor 150 Metcalfe Street Ottawa, Ontario K2P 1P1, CA
Priority Data:
60/045,81007.05.1997US
Title (EN) 4-AZA-STEROIDS AS INHIBITORS OF TESTOSTERONE-5-ALPHA-REDUCTASE
(FR) 4-AZASTEROIDES
Abstract:
(EN) Novel 4-aza-steroid compounds are provided, which have functional groups at one or more of positions 7, 11 and 15, such as hydroxyl or hydroxyl derivative groups. The compounds are active against 5-$g(a)-reductase giving indications of utility in combating prostate cancer. The novel compounds can be prepared by chemo-enzymatic synthesis from easily available 4-aza-steroids.
(FR) L'invention concerne de nouveaux 4-azastéroïdes, qui comportent des groupes fonctionnels au niveau d'une ou de plusieurs positions 7, 11 et 15, tels que des groupes hydroxy ou dérivés d'hydroxy. Ces composés sont actifs contre la 5-$g(a)-réductase, ce qui indique qu'ils peuvent être utiles pour lutter contre le cancer de la prostate. Ils peuvent être préparés par synthèse chimio-enzymatique à partir de 4-azastéroïdes faciles à se procurer.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0983295US20020035260JP2001523259 CA2287924AU1998073277