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1. (WO1998050406) CELL PROLIFERATION RELATED GENES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050406 International Application No.: PCT/US1998/009453
Publication Date: 12.11.1998 International Filing Date: 08.05.1998
Chapter 2 Demand Filed: 26.10.1998
IPC:
A61K 38/00 (2006.01) ,C07K 14/47 (2006.01) ,C12N 9/64 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
64
derived from animal tissue, e.g. rennin
Applicants:
THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street Boston, MA 02110, US (AllExceptUS)
ZERVOS, Antonis, S. [GR/US]; US (UsOnly)
Inventors:
ZERVOS, Antonis, S.; US
Agent:
MYERS, Paul, Louis ; Fish & Richardson P.C. 225 Franklin Street Boston, MA 02110-2804, US
Priority Data:
60/046,07709.05.1997US
Title (EN) CELL PROLIFERATION RELATED GENES
(FR) GENES ASSOCIES A LA PROLIFERATION CELLULAIRE
Abstract:
(EN) The present invention relates to three novel cancer related genes, Nmi, Omi and Rim. The Nmi gene encodes a myc gene product-binding protein. The Omi gene encodes a mammalian serine protease protein comprising an amino terminal regulatory domain, which includes a signal peptidase site, a triple repeat motif, an SH3 binding domain, and a consensus Mxi2/p38 kinase phosphorylation site, and a carboxy terminus serine protease catalytic domain. The retinoblastoma-interacting myosin-like gene (Rim gene) encodes a retinoblastoma binding protein comprising two leucine zipper structures, an RB family binding motif, an E1A / CtBP binding motif, and four nuclear localization sequences. Described herein are isolated and antisense nucleic acids molecules, recombinant expression vectors, host cells and non-human transgenic animals containing an insertion or a disruption of the Nmi, Omi and Rim genes. Diagnostic, screening and therapeutic methods utilizing the compositions of the invention are also provided.
(FR) La présente invention concerne trois nouveaux gènes associés au cancer, Nmi, Omi, et Rim. Le gène Nmi code une protéine de fixation au produit génique myc, le gène Omi code une protéine de sérine protéase mammifère renfermant un domaine régulateur aminé terminal, lequel comprend un site peptidase signal, un motif à triple répétition, un domaine de fixation SH3, un site consensus de phosphorylation de Mxi2/p38 kinase, et un domaine catalytique de sérine protéase à terminaison carboxy. Le gène apparenté à la myosine en interaction avec le rétinoblastome (ou gène Rim) code une protéine de fixation au rétinoblastome, laquelle comprend deux structures de glissière à leucine, un motif de fixation de la famille RB, un motif de fixation aux fragments E1A/CtBP, et quatre séquences de localisation nucléaire. L'invention concerne également des molécules d'acide nucléique isolées et antisens, des vecteurs d'expression recombinés, des cellules hôtes et des animaux transgéniques contenant une insertion ou une rupture desdits gènes Nmi, Omi, et Rim. L'invention concerne enfin des méthodes diagnostique, thérapeutique et de criblage utilisant les compositions de cette invention.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998074761