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1. (WO1998050399) AMINOALKYL GLUCOSAMINE PHOSPHATE COMPOUNDS AND THEIR USE AS ADJUVANTS AND IMMUNOEFFECTORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050399 International Application No.: PCT/US1998/009385
Publication Date: 12.11.1998 International Filing Date: 07.05.1998
Chapter 2 Demand Filed: 16.11.1998
IPC:
C07H 15/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15
Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
02
Acyclic radicals, not substituted by cyclic structures
04
attached to an oxygen atom of a saccharide radical
Applicants:
CORIXA CORPORATION [US/US]; Suite 200 1124 Columbia Street Seattle, WA 98104, US
Inventors:
JOHNSON, David, A.; US
SOWELL, C., Gregory; US
Agent:
KYLE, Jean ; Saliwanchik, Lloyd & Saliwanchik, P.C. P.O. Box 2274, Hamilton, MT 59840-4274, US
Priority Data:
08/853,82608.05.1997US
Title (EN) AMINOALKYL GLUCOSAMINE PHOSPHATE COMPOUNDS AND THEIR USE AS ADJUVANTS AND IMMUNOEFFECTORS
(FR) COMPOSES D'AMINOALKYLE GLUCOSAMINE PHOSPHATES ET LEUR UTILISATION COMME ADJUVANTS ET IMMUNOEFFECTEURS
Abstract:
(EN) Aminoalkyl glucosamine phosphate compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosamine ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Methods for using the compounds as adjuvants and immunoeffectors are also disclosed.
(FR) La présente invention concerne des composés d'aminoalkyle glucosamine phosphates qui sont des adjuvants et des immunoeffecteurs. Ces composés ont un 2-désoxy-2-aminoglucose en liaison glucidique avec un groupe aminoalkyle (aglycon). Ces composés sont phosphorylés au niveau du carbone 4 ou 6 sur le noyau de glucoseamine et comprennent trois résidus 3-alcanoyloxyalcanoyle. Les composés augmentent la production d'anticorps chez des animaux immunisés, stimulent la production de cytokine et activent des macrophages. La présente invention concerne également des procédés d'utilisation de ces composés comme adjuvants et immunoeffecteurs.
Designated States: AL, AU, BA, BB, BG, BR, CA, CN, CU, CZ, EE, GE, GW, HU, ID, IL, IS, JP, KP, KR, LC, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, SL, TR, TT, UA, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXPA/a/1999/010262APAP 1181KR1020010012333IL132739EP0983286JP2002512623
CN1265112CA2288601BRPI9809791NZ500938AU1998074747DK0983286