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1. (WO1998050384) TRICYCLIC PYRIDONE ANALOGUES AS GABA-A RECEPTOR LIGANDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050384 International Application No.: PCT/GB1998/001167
Publication Date: 12.11.1998 International Filing Date: 22.04.1998
Chapter 2 Demand Filed: 19.10.1998
IPC:
C07D 471/04 (2006.01) ,C07D 471/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
Applicants:
MERCK SHARP & DOHME LIMITED [GB/GB]; Hertford Road Hoddesdon Hertfordshire EN11 9BU, GB (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
HARRISON, Timothy [GB/GB]; GB (UsOnly)
MOYES, Christopher, Richard [GB/GB]; GB (UsOnly)
NADIN, Alan [GB/GB]; GB (UsOnly)
OWENS, Andrew, Pate [GB/GB]; GB (UsOnly)
LEWIS, Richard, Thomas [GB/GB]; GB (UsOnly)
Inventors:
HARRISON, Timothy; GB
MOYES, Christopher, Richard; GB
NADIN, Alan; GB
OWENS, Andrew, Pate; GB
LEWIS, Richard, Thomas; GB
Agent:
THOMPSON, John; Merck & Co., Inc. European Patent Dept. Terlings Park, Eastwick Road Harlow Essex CM20 2QR, GB
Priority Data:
9708945.201.05.1997GB
Title (EN) TRICYCLIC PYRIDONE ANALOGUES AS GABA-A RECEPTOR LIGANDS
(FR) ANALOGUES DE PYRIDONE TRICYCLIQUE UTILISES COMME LIGANDS DE RECEPTEURS GABA-A
Abstract:
(EN) A class of tricyclic pyridin-2-one analogues, substituted at the 3-position of the pyridone ring by an ester or thiazole moiety, are selective ligands for GABAA receptors, in particular having high affinity for the $g(a)2 and/or $g(a)3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
(FR) L'invention concerne une classe d'analogues de pyridin-2-one tricyclique, substitués en position 3 du noyau pyridone par un ester ou une fraction thiazole. Ces analogues sont des ligands sélectifs de récepteurs GABAA. Ils présentent en particulier une grande affinité pour la sous-unité $g(a)2 et/ou à la sous-unité $g(a)3 de ces récepteurs et sont par conséquent utiles dans le traitement et/ou la prévention de troubles du système nerveux central, notamment l'anxiété et les convulsions.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0980371US6133255JP2001522375 CA2287929AU1998070661