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Machine translation
1. (WO1998050378) PROCESS FOR CONVERTING 9-DIHYDRO-13-ACETYLBACCATIN III INTO TAXOL AND DERIVATIVES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/050378    International Application No.:    PCT/CA1998/000401
Publication Date: 12.11.1998 International Filing Date: 01.05.1998
Chapter 2 Demand Filed:    22.10.1998    
IPC:
C07D 305/14 (2006.01)
Applicants: LIU, Jian [CA/CA]; (CA)
Inventors: LIU, Jian; (CA)
Agent: SEABY & MACLEAN; 603-880 Wellington Street, Ottawa, Ontario K1R 6K7 (CA)
Priority Data:
2,204,197 01.05.1997 CA
Title (EN) PROCESS FOR CONVERTING 9-DIHYDRO-13-ACETYLBACCATIN III INTO TAXOL AND DERIVATIVES THEREOF
(FR) PROCEDE DE CONVERSION DE LA 9-DIHYDRO-13-ACETYLBACCATINE III EN TAXOL ET SES DERIVES
Abstract: front page image
(EN)A process for the preparation of taxol, analogs thereof and their intermediates is described. The process includes the steps of protecting the C-7 hydroxy group of 9-dihydro-13-acetylbaccatin III with a suitable protecting group; oxidizing the C-9 hydroxy group; and adding a suitable side chain to the C-13 position. The intermediates include a compound having formula (1) wherein R is selected from the group consisting of benzyl, substituted benzyl, benzylformate, substituted benzylformate, tosyl, substituted tosyl, dihydropyran, methoxymethyl, benzoyl and substituted benzoyl.
(FR)L'invention concerne un procédé permettant de préparer du Taxol et des analogues du Taxol, ainsi que leurs intermédiaires. Selon le procédé, on protège le groupe hydroxy en C7 de la 9-dihydro-13-acétylbaccatine III par un groupe protecteur approprié; on oxyde le groupe hydroxy en C9; et on ajoute un chaîne latérale appropriée en position C13. Parmi les intermédiaires, on trouve un composé de formule (1), dans laquelle R est choisi dans le groupe comprenant benzyle, benzyle substitué, benzylformate, benzylformate substitué, tosyle, tosyle substitué, dihydropyrane, méthoxyméthyle, benzoyle et benzoyle substitué.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)