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1. (WO1998050347) NAPHTHOLS USEFUL IN ANTIVIRAL METHODS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050347 International Application No.: PCT/US1998/008815
Publication Date: 12.11.1998 International Filing Date: 04.05.1998
Chapter 2 Demand Filed: 25.11.1998
IPC:
C07C 309/35 (2006.01) ,C07D 213/82 (2006.01) ,C07D 309/38 (2006.01) ,C09B 33/04 (2006.01) ,C09B 33/056 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
309
Sulfonic acids; Halides, esters, or anhydrides thereof
01
Sulfonic acids
28
having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
33
of six-membered aromatic rings being part of condensed ring systems
34
formed by two rings
35
Naphthalene sulfonic acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78
Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
81
Amides; Imides
82
in position 3
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
309
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
34
having three or more double bonds between ring members or between ring members and non-ring members
36
with oxygen atoms directly attached to ring carbon atoms
38
one oxygen atom in position 2 or 4, e.g. pyrones
C CHEMISTRY; METALLURGY
09
DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
B
ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
33
Disazo or polyazo dyes of the types A K B, A B K C, or the like, prepared by diazotising and coupling
02
Disazo dyes
04
in which the coupling component is a dihydroxy or polyhydroxy compound
C CHEMISTRY; METALLURGY
09
DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
B
ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES; MORDANTS; LAKES
33
Disazo or polyazo dyes of the types A K B, A B K C, or the like, prepared by diazotising and coupling
02
Disazo dyes
04
in which the coupling component is a dihydroxy or polyhydroxy compound
056
the coupling component being a bis-(naphthol-urea)
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 5th floor 1111 Franklin Street Oakland, CA 94607-5200, US
Inventors:
KENYON, George, L.; US
STAUBER, Margaret, J.; US
MAURER, Karl; US
EARGLE, Dolan; US
MUSCATE, Angelika; DE
LEAVITT, Andrew; US
ROE, Diana, C.; US
EWING, Todd, J., A.; US
SKILLMAN, Allan, G., Jr.; US
ARNOLD, Edward; US
KUNTZ, Irwin, D.; US
YOUNG, Malin; US
Agent:
SIEBERT, J., Suzanne ; Majestic, Parsons, Siebert & Hsue P.C. Suite 1100 Four Embarcadero Center San Francisco, CA 94111-4106, US
Priority Data:
09/072,48404.05.1998US
60/045,58305.05.1997US
Title (EN) NAPHTHOLS USEFUL IN ANTIVIRAL METHODS
(FR) NAPHTOLS UTILISABLES DANS DES METHODES ANTIVIRALES
Abstract:
(EN) The present invention relates to a novel class of compounds that are potent inhibitors of HIV reverse transcriptase and HIV integrase. In addition to being multienzyme inhibitors, the inventive compounds of the present invention are remarkable in at least two other respects. First, they do not appear to be toxic to cells at typical therapeutic concentrations. Second, they appear to be equally effective against mutant strains of HIV reverse transcriptase commonly found in patients who have developed resistance to current reverse transcriptase inhibitors. Because the inventive compounds show promise in combatting viral resistance and are potent inhibitors of both HIV reverse transcriptase and integrase, they are ideal candidates for use in combination with existing therapies or alone in treating AIDS or HIV infection.
(FR) L'invention porte sur une nouvelle classe de composés s'avérant de puissants inhibiteurs de la transcriptase inverse du VIH, et de l'intégrase du VIH. Outre leur fonction d'inhibiteurs multienzymes, lesdits composés sont remarquables à deux autres titres: (1) ils ne semblent pas toxiques pour les cellules, aux concentrations thérapeutiques usuelles; (2) ils semblent présenter la même efficacité vis à vis des souches mutantes de la transcriptase inverse du VIH fréquemment présente chez les patients ayant développé une résistance aux inhibiteurs usuels de la transcriptase inverse. Ces composés, se montrant prometteurs dans le combat contre la résistance aux virus et de puissants inhibiteurs de la transcriptase inverse et de l'intégrase du VIH, sont des candidats idéaux pour être utilisés en combinaison avec des thérapies existantes, ou isolément, pour traiter le SIDA ou les infections par le VIH.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998072735