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1. (WO1998050343) (HETERO)ARYL CARBOXAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS

Pub. No.:    WO/1998/050343    International Application No.:    PCT/EP1998/002266
Publication Date: Fri Nov 13 00:59:59 CET 1998 International Filing Date: Wed Apr 15 01:59:59 CEST 1998
IPC: C07C 233/75
C07D 215/50
Applicants: SMITHKLINE BEECHAM PLC
WYMAN, Paul, Adrian
Inventors: WYMAN, Paul, Adrian
Title: (HETERO)ARYL CARBOXAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS
Abstract:
Compounds of formula (I), processes for their preparation and their use as CNS agents are disclosed, in which Ra is a group of formula (i), in which P1 is bicyclic aryl, a bicyclic heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur; or Ra is a group of formula (ii), wherein P?2 and P3¿ are independently phenyl, bicyclic aryl, a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or a bicyclic heterocyclic group containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulphur providing that at least one of P?2 and P3¿ is a bicyclic aryl or bicyclic heterocyclic group; A is a bond or oxygen, S(O)¿m? where m is 0 to 2, carbonyl, or CH2 or NR?4¿; L is a group of formula -C(=V)-DG - or -DG-C(=V)-; V is oxygen or sulphur; D is nitrogen, carbon or a CH group, G is hydrogen or C¿1-6?alkyl, providing that D is nitrogen or a CH group, or G together with R?b1¿ forms a group W where W is (CR16R17)t or (CR16R17)u-J where u is 0, 1, 2 or 3 and J is oxygen, sulphur, CR?16=CR17, CR16=N, =CR16O, =CR16¿S or =CR16-NR17; B is oxygen, S(O)p where p is 0, 1 or 2, NR6 where R6 is hydrogen or C¿1-6?alkyl or B is CR?7=CR8¿ where R?7 and R8¿ are independently hydrogen or C¿1-6?alkyl; R?c and Rd¿ are independently hydrogen or C¿1-6?alkyl; R?y¿ is a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulphur, or Ry is a group of formula -NReRf.