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1. (WO1998050325) BUILDING BLOCKS DERIVED FROM 1,2-AMINOALCOHOLS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/050325 International Application No.: PCT/US1998/009383
Publication Date: 12.11.1998 International Filing Date: 08.05.1998
Chapter 2 Demand Filed: 12.11.1998
IPC:
C07B 61/00 (2006.01) ,C07C 211/13 (2006.01) ,C07C 291/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
61
Other general methods
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
211
Compounds containing amino groups bound to a carbon skeleton
01
having amino groups bound to acyclic carbon atoms
02
of an acyclic saturated carbon skeleton
13
Amines containing three or more amino groups bound to the carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
291
Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/-C07C281/144
10
Isocyanides
Applicants:
GABRIEL, Richard, L. [US/US]; US (UsOnly)
JURAYJ, Jurjus [LB/US]; US (UsOnly)
PHARM-ECO LABORATORIES, INC. [US/US]; 128 Spring Street Lexington, MA 02173, US (AllExceptUS)
Inventors:
GABRIEL, Richard, L.; US
JURAYJ, Jurjus; US
Agent:
PIERCE, N., Scott ; Hamilton, Brook, Smith & Reynolds, P.C. Two Militia Drive Lexington, MA 02173, US
Priority Data:
60/046,12909.05.1997US
Title (EN) BUILDING BLOCKS DERIVED FROM 1,2-AMINOALCOHOLS
(FR) BLOCS DE CONSTRUCTION DE DERIVES DE 1,2-AMINO-ALCOOLS
Abstract:
(EN) Disclosed are novel compounds represented by structural Formula (XX), (XXI) or (XXII); R1, R21 and R22 are independently an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. R2 and R12 are independently -NR4R5 or -N+$m(Z)C-. R3 is -H or an alcohol protecting group. R4 and R5 are independently -H or an amine protecting group. R11 is a side chain of a naturally occurring amino acid or a protected side chain of a naturally occurring amino acid. R1 and R2, and R11 and R12, taken together with the methine group to which they are bonded, can form a moiety represented by structural Formula (XXIII). R6 is -H or an amine protecting group. R7 is -H, -OH or -OR8. R8 is an alcohol protecting group. Also disclosed are methods of preparing these compounds.
(FR) La présente invention concerne de nouveaux composés représentés par la formule structurale (XX), (XXI) ou (XXII) dans lesquelles R1, R21 et R22 sont indépendamment un groupe aliphatique, un groupe aliphatique substitué, un groupe aromatique ou un groupe aromatique substitué; R2 et R12 sont indépendamment -NR4R5 ou -N+$m(Z)C-; R3 est -H ou un groupe protecteur d'alcool; R4 et R5 sont indépendamment -H ou un groupe protecteur d'amine; R11 est une chaîne latérale d'un amino acide naturel ou une chaîne latérale protégée d'un amino acide naturel; et R1 et R2 ainsi que R11 et R12, pris ensemble avec le groupe méthine auquel ils sont liés, peuvent former une fraction représentée par la formule structurale (XXIII); R6 est -H ou un groupe protecteur d'amine; R7 est -H, -OH ou -OR8; R8 est un groupe protecteur d'alcool. L'invention concerne également des procédés de préparation desdits composés.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)