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1. (WO1998050078) LIPOPHILIC AND/OR LYTIC PEPTIDES FOR SPECIFIC DELIVERY OF NUCLEIC ACIDS TO CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050078 International Application No.: PCT/US1998/008849
Publication Date: 12.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 26.11.1998
IPC:
A61K 47/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
GENEMEDICINE, INC. [US/US]; 8301 New Trails Drive The Woodlands, TX 77381-4248, US (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
BAYLOR COLLEGE OF MEDICINE [US/US]; One Baylor Plaza Houston, TX 77030, US (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
WADWHA, Manpreet, S. [IN/US]; US (UsOnly)
ROLLAND, Alain [FR/US]; US (UsOnly)
SMITH, Louis, C. [US/US]; US (UsOnly)
LOGAN, Mark [US/US]; US (UsOnly)
SPARROW, James, T. [US/US]; US (UsOnly)
Inventors:
WADWHA, Manpreet, S.; US
ROLLAND, Alain; US
SMITH, Louis, C.; US
LOGAN, Mark; US
SPARROW, James, T.; US
Agent:
WARBURG, Richard, J. ; Lyon & Lyon LLP Suite 4700 633 West Fifth Street Los Angeles, CA 90071-2066, US
MOON, Donald, Keith; Brewer & Son Quality House Quality Court Chancery Lane London WC2A 1HT, GB
Priority Data:
60/045,29502.05.1997US
Title (EN) LIPOPHILIC AND/OR LYTIC PEPTIDES FOR SPECIFIC DELIVERY OF NUCLEIC ACIDS TO CELLS
(FR) PEPTIDES LIPOPHILES ET/OU LYTIQUES PERMETTANT L'APPORT SPECIFIQUE D'ACIDES NUCLEIQUES A DES CELLULES
Abstract:
(EN) The invention relates in part to molecular complexes for delivering macromolecules (e.g., nucleic acid molecules) into cells. These molecular complexes can comprise lipophilic peptides that condense and stabilize the macromolecule. These lipophilic binding peptides can also comprise moieties that target the macromolecule to specific cells in an organism. In addition, the molecular complexes can comprise lipophilic peptides that can lyse endosomal structures within cells and thereby enhance delivery of the macromolecule into cells. The invention also relates in part to methods of delivering macromolecules to cells using the molecular complexes described herein. Thus, the present invention provides for efficient and specific delivery of nucleic acid molecules into cells.
(FR) L'invention concerne des complexes moléculaires permettant l'apport de macromolécules (p.ex. molécules d'acide nucléique) à des cellules. Ces complexes moléculaires peuvent comprendre des peptides lipophiles qui condensent et stabilisent la macromolécule. Ces peptides liants lipophiles peuvent également comporter des fractions qui acheminent la macromolécule de façon ciblée vers des cellules spécifiques de l'organisme. Les complexes moléculaires peuvent également comprendre des peptides lipophiles pouvant entraîner la lyse de structures endosomales internes aux cellules et augmenter ainsi l'apport de macromolécules à l'intérieur des cellules. L'invention concerne également des procédés permettant l'apport de macromolécules à des cellules à l'aide des complexes moléculaires décrits. La présente invention assure ainsi l'apport efficace et spécifique de molécules d'acide nucléique dans les cellules.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998071736