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1. (WO1998050061) NOVEL THERAPIES FOR CYSTIC KIDNEY DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050061 International Application No.: PCT/US1998/009268
Publication Date: 12.11.1998 International Filing Date: 06.05.1998
IPC:
A61K 38/18 (2006.01) ,A61K 48/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
18
Growth factors; Growth regulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Applicants:
BIOGEN, INC. [US/US]; 14 Cambridge Center Cambridge, MA 02142, US (AllExceptUS)
GJORSTRUP, Per [SE/US]; US (UsOnly)
HARRIS, Ray [US/US]; US (UsOnly)
Inventors:
GJORSTRUP, Per; US
HARRIS, Ray; US
Agent:
KAPLAN, Warren, A.; Biogen, Inc. 14 Cambridge Center Cambridge, MA 02142, US
Priority Data:
60/045,90907.05.1997US
Title (EN) NOVEL THERAPIES FOR CYSTIC KIDNEY DISEASE
(FR) NOUVELLES THERAPIES DES MALADIES KYSTIQUES RENALES
Abstract:
(EN) Methods for treating cystic kidney disease are described. The method includes administering to a subject having, or susceptible to, the disease, an effective amount of a renal therapeutic agent or polynucleotide encoding the protein. Renal therapeutic agents are isolated, renal therapeutic molecules that preferably are selected from a member of an osteogenic protein/bone morphogenic protein (OP/BMP) family within a transforming growth factor-beta superfamily of proteins. A particulary preferred agent has at least 60 % amino acid sequence homology with the group consisting of SEQ ID NOS: 1-5.
(FR) Cette invention se rapporte à une méthode de traitement des maladies kystiques rénales. Cette méthode consiste à administrer à un sujet ayant contracté, ou susceptible de contracter, la maladie, une quantité efficace d'un agent thérapeutique rénal ou d'un polynucléotide codant la protéine correspondante. On isole des agents thérapeutiques rénaux, qui sont de préférence des molécules thérapeutiques rénales sélectionnées à partir d'un élément d'une famille de protéines ostéogéniques / de protéines morphogéniques osseuses (OP/BMP) appartenant à une superfamille de protéines du facteur de croissance transformant bêta. Un agent particulièrement préféré comporte au minimum 60 % d'homologie d'une séquence d'acide aminé avec le groupe constitué de la séquence SEQ ID NOS:1-5.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998074730