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1. (WO1998050053) GENE TRANSFER WITH ADENOVIRUSES HAVING MODIFIED FIBER PROTEINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050053 International Application No.: PCT/US1998/008570
Publication Date: 12.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 15.10.1998
IPC:
C07K 14/075 (2006.01) ,C12N 15/861 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
075
Adenoviridae
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
861
Adenoviral vectors
Applicants:
GENETIC THERAPY, INC. [US/US]; 938 Clopper Road Gaithersburg, MD 20878, US (AL, AM, AT, AU, AZ, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, HU, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, ZW)
McCLELLAND, Alan [US/US]; US (UsOnly)
STEVENSON, Susan, C. [US/US]; US (UsOnly)
GORZIGLIA, Mario [VE/US]; US (UsOnly)
VANIN, Elio, F. [AU/US]; US (UsOnly)
Inventors:
McCLELLAND, Alan; US
STEVENSON, Susan, C.; US
GORZIGLIA, Mario; US
VANIN, Elio, F.; US
Agent:
LILLIE, Raymond, J. ; Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein 6 Becker Farm Road Roseland, NJ 07068, US
Priority Data:
08/852,92408.05.1997US
Title (EN) GENE TRANSFER WITH ADENOVIRUSES HAVING MODIFIED FIBER PROTEINS
(FR) TRANSFERT DE GENES A L'AIDE D'ADENOVIRUS COMPRENANT DES PROTEINES FIBREUSES MODIFIEES
Abstract:
(EN) A method of transferring at least one DNA sequence into cells by transducing the cells, $i(in vivo) or $i(ex vivo), with a modified adenovirus. The adenovirus, prior to modification, is of a first serotype. In the modified adenovirus, at least a portion of the fiber, and in particular the head portion, is removed from the adenovirus of the first serotype and replaced with a portion, in particular the head portion, of the fiber of an adenovirus of a second serotype. Such method is useful in transducing cells which may be refractory to the adenovirus of the first serotype, yet include a receptor which binds to the head portion of the fiber of the adenovirus of the second serotype.
(FR) Procédé permettant de transférer au moins une séquence d'ADN dans des cellules par transduction des cellules, in vivo ou ex vivo, avec un adénovirus modifié. Avant sa modification, l'adénovirus est d'un premier sérotype. Dans l'adénovirus modifé, au moins une partie de la fibre, et plus particulièrement la partie tête, est éliminée de l'adénovirus du premier sérotype et remplacée par une partie, plus particulièrement la partie de tête, de la fibre d'un adénovirus d'un deuxième sérotype. Ce procédé est utile dans la transduction de cellules qui peuvent être résistantes à l'adénovirus du premier sérotype, mais qui comprennent cependant un récepteur qui se lie à la partie tête de la fibre de l'adénovirus du deuxième sérotype.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL132673EP1015005JP2002513290 CA2289215NZ500791AU1998072632
AU2002034384