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1. (WO1998050038) USE OF QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/050038    International Application No.:    PCT/US1998/008482
Publication Date: 12.11.1998 International Filing Date: 28.04.1998
Chapter 2 Demand Filed:    04.12.1998    
IPC:
A61K 31/517 (2006.01)
Applicants: AMERICAN CYANAMID COMPANY [US/US]; Five Giralda Farms, Madison, NJ 07940-0874 (US)
Inventors: FROST, Philip; (US)
Agent: ALICE, Ronald, W.; American Home Products Corporation, Patent Law Dept. -2B, One Campus Drive, Parsippany, NJ 07054 (US).
WILEMAN, David Francis; c/o Wyeth Laboratories, Huntercombe Lane South, Taplow Maidenhead Berks SL6 0PH (GB)
Priority Data:
08/852,266 06.05.1997 US
Title (EN) USE OF QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE
(FR) UTILISATION DE COMPOSES DE LA QUINAZOLINE DANS LE TRAITEMENT DE LA MALADIE POLYKYSTIQUE DES REINS
Abstract: front page image
(EN)This invention provides a method of treating or inhibiting polycystic kidney disease in a mammal in need thereof which comprises administering to said mammal a compound having formula (1) wherein X is phenyl which is optionally substituted; R and R1 are each, independently, hydrogen, halogen, alkyl, alkoxy, hydroxy, or trifluoromethyl; R2 is hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl; Y is a radical selected from the group consisting of (a), (b), (c), (d), (e), (f) and (g); R3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl; n = 2-4; or a pharmaceutically acceptable salt thereof, with the proviso that each R3 of Y may be the same or different.
(FR)La présente invention concerne un procédé permettant de traiter ou de prévenir la maladie polykystique des reins chez un mammifère dont l'état justifie ce traitement, lequel procédé consiste à administrer au dit mammifère un composé de la formule (1) dans laquelle X est un phényle facultativement substitué; R et R1 sont chacun indépendamment hydrogène, halogène, alkyle, alcoxy, hydroxy ou trifluorométhyle; R2 est hydrogène, alkyle, alcoxy, hydroxy, trifluorométhyle; Y est un radical choisi dans le groupe composé de (a), (b), (c), (d), (e), (f) et (g); R3 est indépendamment hydrogène, alkyle, carboxy, carboalcoxy, phényle ou carboalkyle; n=2-4; ou un sel pharmaceutiquement acceptable de ce composé, à condition que chaque R3 de Y puisse être le même ou différent.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)