Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO1998050033) COX-2 SELECTIVE CARPROFEN FOR TREATING PAIN AND INFLAMMATION IN DOGS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/050033 International Application No.: PCT/IB1998/000662
Publication Date: 12.11.1998 International Filing Date: 01.05.1998
Chapter 2 Demand Filed: 23.09.1998
IPC:
A61K 31/40 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
Applicants:
PFIZER INC. [US/US]; 235 East 42nd Street New York, NY 10017, US (AllExceptUS)
LUNDY, Kristin, Marie [US/US]; US (UsOnly)
RICKETTS, Anthony, Paul [GB/US]; US (UsOnly)
Inventors:
LUNDY, Kristin, Marie; US
RICKETTS, Anthony, Paul; US
Agent:
SPIEGEL, Allen, J.; c/o Mark Charles Green Urquhart-Dykes & Lord 91 Wimpole Street London W1M 8AH , GB
SPIEGEL, Allen, J.; c/o Simpson, Alison Urquhart-Dykes & Lord 91 Wimpole Street London W1M 8AH, GB
Priority Data:
60/045,63505.05.1997US
Title (EN) COX-2 SELECTIVE CARPROFEN FOR TREATING PAIN AND INFLAMMATION IN DOGS
(FR) CARPROFENE INHIBANT SELECTIVEMENT COX-2 ET UTILISE DANS LE TRAITEMENT DE LA DOULEUR ET DES INFLAMMATIONS CHEZ LES CHIENS
Abstract:
(EN) Treating or preventing inflammatory processes and diseases in dogs associated with the activity of inducible cyclo-oxygenase-2 (COX-2), while at the same time reducing or eliminating undesirable side effects associated with simultaneous inhibition of the activity of constitutive cyclo-oxygenase-1 (COX-1) by selectively inhibiting COX-2 activity with reference to COX-1 activity, wherein the selectivity ratio or COX-2 : COX-1 activity inhibition is at least 3 : 1 based on $i(ex vivo) inhibition levels measured in whole blood; the inhibitor is a member selected from the group of anti-inflammatory compounds consisting essentially of salicylic acid derivatives, $i(p)-aminophenol derivatives, indole and indene acetic acids, heteroaryl acetic acids, arylpropionic acids, anthranilic acids, enolic acids, and alkanones; the inhibitor in particular is comprised of (+)$i((S))-enantiomer of 6-chloro-$g(a)-methyl-9$i(H)-carbazole-2-acetic acid.
(FR) L'invention porte sur des procédés de traitement ou de prévention des inflammations chez les chiens ou des maladies associées à l'activité de cyclo-oxygénase-2 (COX-2) inductive, et simultanément sur la réduction ou l'élimination d'effets secondaires indésirables associés à l'inhibition simultanée de l'activité de cyclo-oxygénase-1 (COX-1) constitutive en sélectionnant sélectivement l'activité de COX-2 en tenant compte de l'activité de COX-1, le rapport de sélectivité ou d'inhibition de l'activité de COX-2 : COX-1 étant au moins de 3 : 1 sur la base des taux d'inhibition $i(ex vivo) relevés dans le sang entier; l'inhibiteur est un élément sélectionné dans le groupe des composés anti-inflammatoires constitués principalement des dérives d'acide salicylique, des dérivés de $i(p)-aminophénol, d'indole et des acides acétiques d'indène, des acides acétiques d'hétéroaryle, des acides arylproprioniques, des acides anthraniliques, des acides énoliques et des alcanones; l'inhibiteur comprend notamment (+)$i((S))-énantiomère de l'acide 6-chloro-$g(a)-méthyl-9$i(H)-carbazole-2-acétique.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1999-3896IS5220NO19995389SK148199YUP-558/99MXPA/a/1999/010148
KR1020010012300KR1020040004406IL132570AR039628MA26491UY0001028000
EP0988034US20030212123JP2000513020 CN1255059CA2288759EA199900895
NZ500183NZ516914AU1998069321AU2002038232ID021.311MYPI 98001979