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1. (WO1998050024) 8-ISO-PROSTAGLANDINS FOR GLAUCOMA THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/050024 International Application No.: PCT/US1998/009090
Publication Date: 12.11.1998 International Filing Date: 06.05.1998
Chapter 2 Demand Filed: 30.11.1998
IPC:
A61K 31/5575 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
557
Eicosanoids, e.g. leukotrienes
5575
having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
Applicants: PODOS, Steven, M.[US/US]; US (UsOnly)
MITTAG, Thomas, W.[US/US]; US (UsOnly)
BECKER, Bernard[US/US]; US (UsOnly)
THE MOUNT SINAI SCHOOL OF MEDICINE OF THE CITY UNIVERSITY OF NEW YORK[US/US]; One Gustave L. Levy Place New York, NY 10029, US (AllExceptUS)
Inventors: PODOS, Steven, M.; US
MITTAG, Thomas, W.; US
BECKER, Bernard; US
Agent: CLARK, Richard, S. ; Baker & Botts, LLP 30 Rockefeller Plaza New York, NY 10112-0228, US
Priority Data:
08/853,80309.05.1997US
Title (EN) 8-ISO-PROSTAGLANDINS FOR GLAUCOMA THERAPY
(FR) TRAITEMENT DU GLAUCOME A BASE DE 8-ISO-PROSTAGLANDINES
Abstract:
(EN) The present invention relates to the use of 8-iso prostaglandins and their derivatives for decreasing intraocular pressure, for example in the treatment of glaucoma. It is based, at least in part, on the discovery that 8-iso prostaglandin E2 effectively decreased intraocular pressure by a trabecular meshwork outflow mechanism.
(FR) L'invention concerne l'utilisation des 8-iso-prostaglandines et de leurs dérivés pour faire baisser la tension intra-oculaire, par exemple dans le traitement du glaucome. Elle se caractérise, au moins en partie, par la découverte de l'action de la 8-iso-prostaglandine E2, qui fait baisser efficacement la tension intra-oculaire par un mécanisme d'évacuation du trabéculum.
Designated States: AU, CA, JP, US
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)