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1. (WO1998049969) CHEMICAL CLEANING OF BIOLOGICAL MATERIAL
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/049969 International Application No.: PCT/US1998/009432
Publication Date: 12.11.1998 International Filing Date: 08.05.1998
Chapter 2 Demand Filed: 04.12.1998
IPC:
A61L 27/36 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
36
containing ingredients of undetermined constitution or reaction products thereof
Applicants:
ABRAHAM, Ginger, A. [US/US]; US (UsOnly)
CARR, Robert, M., Jr. [US/US]; US (UsOnly)
KEMP, Paul, D. [GB/GB]; GB (UsOnly)
MERCER, Ryan [US/US]; US (UsOnly)
BAKER, Linda [US/US]; US (UsOnly)
ORGANOGENESIS INC. [US/US]; 150 Dan Road Canton, MA 02021, US (AllExceptUS)
Inventors:
ABRAHAM, Ginger, A.; US
CARR, Robert, M., Jr.; US
KEMP, Paul, D.; GB
MERCER, Ryan; US
BAKER, Linda; US
Agent:
BAKER, Hollie, L. ; Hale and Dorr LLP 60 State Street Boston, MA 02109, US
Priority Data:
08/853,37208.05.1997US
Title (EN) CHEMICAL CLEANING OF BIOLOGICAL MATERIAL
(FR) NETTOYAGE CHIMIQUE DE MATIERE BIOLOGIQUE
Abstract:
(EN) The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.
(FR) L'invention concerne des tissus collagènes traités de manière à éliminer les composants non collagènes tels que des cellules, des débris cellulaires, ainsi que d'autres composants de matrice extracellulaire, par exemple les protéoglycanes et les glycosaminoglycanes, que l'on trouve habituellement dans les tissus d'origine. Le traitement de ces tissus à l'aide d'agents chélateurs alcalins, d'acides, et de sels permet d'éliminer les composants non collagènes de la matrice tissulaire collagène, tout en régulant son gonflement et sa dissolution, de sorte que la matrice collagène ainsi obtenue conserve son organisation et son intégrité structurelles ainsi que ses propriétés bioremodelables. Le procédé de cette invention permet d'éviter l'utilisation de détergents et d'enzymes qui pourraient nuire à la compatibilité, à la solidité, et à la bioremodelabilité cellulaire de ladite matrice collagène. Cette matrice tissulaire collagène est utilisée, chez un mammifère hôte, à des fins d'implantation, de réparation, ou d'utilisation.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)