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1. (WO1998049900) HALOISOQUINOLINE CARBOXAMIDE

Pub. No.:    WO/1998/049900    International Application No.:    PCT/US1998/009397
Publication Date: Fri Nov 13 00:59:59 CET 1998 International Filing Date: Fri May 08 01:59:59 CEST 1998
IPC: C07D 217/26
Applicants: EMORY UNIVERSITY
Inventors: GOODMAN, Mark, M.
PATTERSON, Randolph, E.
ALEXANDER, R., W.
CHAPPELL, David
Title: HALOISOQUINOLINE CARBOXAMIDE
Abstract:
Compounds of the invention have general structure (A) wherein X, Y or Z are, respectively independently, H, F or an isotope thereof, Br or an isotope thereof, I or an isotope thereof, At or an isotope thereof, (R1)W or (R2)V and R is -(R1)W, when W is H or F or an isotope thereof, R1 is linear or branched alkyl of 1-4 carbon atoms, R2 is vinyl, V is I or an isotope thereof and at least one of X, Y or Z is not H. The compounds of the invention bind to PK receptors.