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1. (WO1998049349) ANTISENSE INHIBITION OF ras GENE WITH CHIMERIC AND ALTERNATING OLIGONUCLEOTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/049349 International Application No.: PCT/US1998/008800
Publication Date: 05.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 25.11.1998
IPC:
C07H 21/00 (2006.01) ,C12N 15/11 (2006.01) ,C12Q 1/68 (2006.01)
Applicants: ECKER, David, J.[US/US]; US (UsOnly)
COOK, Philip, Dan[US/US]; US (UsOnly)
MONIA, Brett, P.[US/US]; US (UsOnly)
FREIER, Susan, M.[US/US]; US (UsOnly)
SANGHVI, Yogesh, S.[US/US]; US (UsOnly)
ISIS PHARMACEUTICALS, INC.[US/US]; 2292 Faraday Avenue Carlsbad, CA 92008, US (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
Inventors: ECKER, David, J.; US
COOK, Philip, Dan; US
MONIA, Brett, P.; US
FREIER, Susan, M.; US
SANGHVI, Yogesh, S.; US
Agent: CALDWELL, John, W. ; Woodcock Washburn Kurtz Mackiewicz & Norris LLP 46th floor One Liberty Place Philadelphia, PA 19103, US
Priority Data:
08/848,84030.04.1997US
Title (EN) ANTISENSE INHIBITION OF ras GENE WITH CHIMERIC AND ALTERNATING OLIGONUCLEOTIDES
(FR) INHIBITION ANTISENS DU GENE ras A L'AIDE D'OLIGONUCLEOTIDES CHIMERIQUES ET A LIAISONS ALTERNEES
Abstract:
(EN) Compositions and methods are provided for the modulation of expression of the human ras gene in both the normal and activated forms. Oligonucleotides are provided that have methylene(methylimino) linkages alternating with phosphorothioate or phosphodiester linkages. Further oligonucleotides are provided that have a first region having a methylene(methylimino) linkage alternating with a phosphorothioate or phosphodiester linkage and a second region having phosphorothioate linkages. Such oligonucleotides can be used for diagnostics as well as for research purposes including methods for diagnosis, detection and treatment of conditions arising from the activation of the H-ras gene.
(FR) Compositions et procédés pour la modulation de l'expression du gène humain ras dans ses formes tant normale qu'activée. La présente invention concerne des oligonucléotides qui possèdent des liaisons méthylène(méthylimino) alternant avec des liaisons phosphorothioate ou phosphodiester. Elle concerne encore d'autres oligonucléotides ayant une première région dotée d'une liaison méthylène(méthylimino) alternant avec une liaison phosphorothioate ou phosphodiester et une seconde région ayant des liaisons phosphorothioate. Ces oligonucléotides peuvent être utilisés pour le diagnostic ainsi que pour la recherche, dans des procédés de diagnostic, de détection et de traitement de maladies résultant de l'activation du gène H-ras.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)