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1. (WO1998049343) METHODS OF IDENTIFYING TRANSITION METAL COMPLEXES THAT SELECTIVELY CLEAVE REGULATORY ELEMENTS OF MRNA AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/049343 International Application No.: PCT/US1998/008460
Publication Date: 05.11.1998 International Filing Date: 27.04.1998
Chapter 2 Demand Filed: 30.11.1998
IPC:
C12N 15/67 (2006.01) ,C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67
General methods for enhancing the expression
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
NORTH CAROLINA STATE UNIVERSITY [US/US]; 1 Holladay Hall Raleigh, NC 27695-7003, US
Inventors:
THEIL, Elizabeth, C.; US
Agent:
DAVIS, Michael, D. ; Klauber & Jackson 411 Hackensack Avenue Hackensack, NJ 07601, US
Priority Data:
08/841,16629.04.1997US
Title (EN) METHODS OF IDENTIFYING TRANSITION METAL COMPLEXES THAT SELECTIVELY CLEAVE REGULATORY ELEMENTS OF MRNA AND USES THEREOF
(FR) METHODES D'IDENTIFICATION DE COMPLEXES DE METAUX DE TRANSITION CLIVANT SELECTIVEMENT LES ELEMENTS REGULATEURS D'ARNM ET LEURS UTILISATIONS
Abstract:
(EN) Methods for selecting transition metal complexes (TMCs) that can modulate the translation of an mRNA by selectively cleaving a regulatory element of the mRNA are described. Included are $i(in vitro), $i(in situ), and/or $i(in vivo) methods. In addition, methods of identifying and characterizing mRNAs that contain regulatory elements which can be targeted by the TMCs of the present invention are also provided. Pharmaceutical compositions containing the TMCs of the present invention are also included.
(FR) L'invention concerne des méthodes permettant de sélectionner des complexes de métaux de transition (TMC) pouvant moduler la traduction d'un ARNm par clivage sélectif d'un élément régulateur de l'ARNm. Ces méthodes peuvent être $i(in vitro, in situ), et/ou $i(in vivo). L'invention concerne également des méthodes d'identification et de caractérisation d'ARNm renfermant des éléments régulateurs pouvant être ciblés par les TMC de la présente invention. L'invention concerne enfin des compositions pharmaceutiques contenant les TMC de l'invention.
Designated States: AL, AU, BA, BB, BG, BR, CA, CN, CU, CZ, EE, GE, GW, HU, ID, IL, IS, JP, KP, KR, LC, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, SL, TR, TT, UA, UZ, VN, YU
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1998072602