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1. (WO1998049339) PROCESS FOR PRODUCING OPTICALLY ACTIVE COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/049339 International Application No.: PCT/JP1998/001963
Publication Date: 05.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 29.10.1998
IPC:
C12P 41/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
41
Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture
Applicants:
DAISO CO., LTD. [JP/JP]; 10-8, Edobori 1-chome Nishi-ku Osaka-shi Osaka 550-0002, JP (AT, BE, CA, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, JP, LU, MC, NL, PT, SE)
NAKAMURA, Kaoru [JP/JP]; JP (UsOnly)
TAKENAKA, Keishi [JP/JP]; JP (UsOnly)
OHNO, Atsuyoshi [JP/JP]; JP (UsOnly)
FURUKAWA, Yoshiro [JP/JP]; JP (UsOnly)
Inventors:
NAKAMURA, Kaoru; JP
TAKENAKA, Keishi; JP
OHNO, Atsuyoshi; JP
FURUKAWA, Yoshiro; JP
Agent:
KISHIMOTO, Einosuke ; Inaba Building 3rd floor 13-18, Nishishinsaibashi 1-chome Chuo-ku, Osaka-shi Osaka 542-0086, JP
Priority Data:
10/7748425.03.1998JP
9/11240930.04.1997JP
Title (EN) PROCESS FOR PRODUCING OPTICALLY ACTIVE COMPOUNDS
(FR) PROCEDE DE PRODUCTION DE COMPOSES OPTIQUEMENT ACTIFS
Abstract:
(EN) A process for synthesizing high yields of alkynyl alcohols having a high optical purity through simple steps by using a relatively inexpensive catalyst. An (R,S) alkynyl alcohol ester (I) is reacted with an alcohol in the presence of a lipase capable of stereoselectively alcoholyzing the ester of either R- or S-form in an organic ether solvent. Thus, one optically active alkynyl alcohol (II) is formed, while the other optically active alkynyl alcohol ester (III) is left behind. In the formulae, R1 represents H or C1-6 alkyl, and R3 represents C6-12 alkyl.
(FR) Procédé qui permet de synthétiser de grandes quantités d'alcynylalcools ayant une pureté optique élevée par des étapes simples avec un catalyseur relativement bon marché. On fait réagir un ester d'alcynylalcool (R, S) (I) avec un alcool en présence d'une lipase capable d'alcooliser stéréosélectivement l'ester sous forme R ou S dans un solvant organique à base d'éther. Il se forme ainsi un alcynylalcool optiquement actif (II), tandis que l'autre ester d'alcynylalcool optiquement actif (III) reste. Dans les formules, R1 représente H ou alkyle C1-C6, et R3 représente alkyle C6-C12.
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Designated States: CA, JP, US
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
JP3550688