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1. (WO1998049336) METASTASIS MODELS USING GREEN FLUORESCENT PROTEIN (GFP) AS A MARKER
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/049336 International Application No.: PCT/US1998/008457
Publication Date: 05.11.1998 International Filing Date: 28.04.1998
Chapter 2 Demand Filed: 09.11.1998
IPC:
A01K 67/027 (2006.01) ,A61K 48/00 (2006.01) ,A61K 49/00 (2006.01) ,C07K 14/435 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
Applicants:
ANTICANCER, INC. [US/US]; 7917 Ostrow Street San Diego, CA 92111, US
Inventors:
TAN, Yuying; US
CHISHIMA, Takashi; JP
Agent:
MURASHIGE, Kate, H. ; Morrison & Foerster LLP 2000 Pennsylvania Avenue, N.W. Washington, DC 20006-1888, US
Priority Data:
08/848,53928.04.1997US
09/049,54427.03.1998US
Title (EN) METASTASIS MODELS USING GREEN FLUORESCENT PROTEIN (GFP) AS A MARKER
(FR) METASTASES MODELES UTILISANT UNE PROTEINE FLUORESCENTE VERTE (GFP) COMME MARQUEUR
Abstract:
(EN) A method to follow the progression of metastasis of a primary tumor, which method comprises removing fresh organ tissues from a vertebrate subject which has been modified to contain tumor cells that express GFP and observing the excised tissues for the presence of fluorescence is disclosed. The fluorescence can also be monitored by observing the tissues $i(in situ). Vertebrate subjects which contain GFP producing tumors are useful models to study the mechanism of metastasis. In addition, subjects already harboring tumors can be treated so as to modify the endogenous tumors to contain GFP. This permits clinical applications. Finally, by injecting a contrast dye into a subject harboring a GFP-labeled tumor, angiogenesis in the tumor can be observed directly.
(FR) L'invention concerne un procédé permettant de suivre la progression des métastases d'une tumeur primitive, lequel procédé consiste à prélever des tissus d'organes vivants chez un sujet vertébré qui a été modifié pour renfermer des cellules tumorales exprimant la GFP, et à détecter la présence de fluorescence dans les tissus excisés. Il est également possible de surveiller la fluorescence par une observation $i(in situ). Les sujets vertébrés renfermant la GFP et produisant des tumeurs constituent des modèles utiles pour l'étude de la métastase. En outre, les sujets hébergeant déjà des tumeurs peuvent être traités de manière à modifier les tumeurs endogènes pour qu'elles renferment la GFP. Cette invention a des applications cliniques. Enfin, on peut observer directement l'angiogenèse en injectant un colorant de contraste dans un sujet hébergeant une tumeur marquée à la GFP.
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Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)