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1. (WO1998049323) FORMS OF PROSTATE SPECIFIC ANTIGEN AND METHODS FOR THEIR DETECTION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/049323 International Application No.: PCT/US1998/008498
Publication Date: 05.11.1998 International Filing Date: 28.04.1998
Chapter 2 Demand Filed: 09.11.1998
IPC:
C07K 16/40 (2006.01) ,C12N 9/64 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
64
derived from animal tissue, e.g. rennin
Applicants:
HYBRITECH INCORPORATED [US/US]; 8958 Terman Court P.O. Box 269006 San Diego, CA 92196-9006, US
Inventors:
SAEDI, Mohammad, S.; US
MIKOLAJCZYK, Stephen, D.; US
KUMAR, Abhay; US
GRAUER, Lana, S.; US
WOLFERT, Robert, L.; US
RITTENHOUSE, Harry, G.; US
Agent:
MAY, William, H. ; Beckman Coulter, Inc. 4300 N. Harbor Boulevard P.O. Box 3100 Fullerton, CA 92834-3100, US
Priority Data:
08/846,40830.04.1997US
Title (EN) FORMS OF PROSTATE SPECIFIC ANTIGEN AND METHODS FOR THEIR DETECTION
(FR) FORMES D'ANTIGENE A SPECIFICITE PROSTATIQUE (ASP) ET LEURS PROCEDES DE DETECTION
Abstract:
(EN) Inactive precursor forms of PSA (pPSA) have been identified. At least one of these forms of pPSA exists in human serum. An expression vector is provided to stably express PSA, in the form of pPSA, in a mammalian system. Methods for detecting inactive precursors of PSA in human physiological fluid are provided. Antibodies specific for pPSA are also provided, as well as diagnostic kits and methods useful in the diagnosis and management of prostate cancer.
(FR) On a identifié des formes inactives de précurseur d'ASP (ASPp). Au moins une de ces formes d'ASPp existe dans du sérum humain. On utilise un vecteur d'expression pour exprimer l'ASP de manière stable sous forme d'ASPp dans un système mammifère. On décrit des procédés permettant de détecter des précurseurs inactifs d'ASP dans du fluide physiologique humain; des anticorps spécifiques contre l'ASPp ainsi que des kits de diagnostic et des procédés utiles dans le diagnostic et le traitement du cancer de la prostate.
Designated States: AU, CA, CN, JP, MX
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)