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1. (WO1998049315) COMBINATORIAL POLYKETIDE LIBRARIES PRODUCED USING A MODULAR PKS GENE CLUSTER AS SCAFFOLD
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/049315 International Application No.: PCT/US1998/008792
Publication Date: 05.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 09.11.1998
IPC:
C07B 61/00 (2006.01) ,C07D 323/00 (2006.01) ,C07H 17/08 (2006.01) ,C12N 15/52 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
61
Other general methods
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
323
Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17
Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04
Heterocyclic radicals containing only oxygen as ring hetero atoms
08
Hetero rings containing eight or more ring members, e.g. erythromycins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
52
Genes encoding for enzymes or proenzymes
Applicants:
KOSAN BIOSCIENCES, INC. [US/US]; 1450 Rollins Road Burlingame, CA 94010, US
THE BOARD OF REGENTS OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; Suite 350 900 Welch Road Palo Alto, CA 94304, US
Inventors:
KHOSLA, Chaitan; US
ASHLEY, Gary; US
FU, Hong; US
KAO, Camilla, M.; US
MCDANIEL, Robert; US
Agent:
MURASHIGE, Kate, H. ; Morrison & Foerster LLP 2000 Pennsylvania Avenue, N.W. Washington, DC 20006-1888, US
Priority Data:
08/846,24730.04.1997US
60/076,91905.03.1998US
Title (EN) COMBINATORIAL POLYKETIDE LIBRARIES PRODUCED USING A MODULAR PKS GENE CLUSTER AS SCAFFOLD
(FR) BIBLIOTHEQUES COMBINATOIRES DE POLYCETIDES PRODUITES A L'AIDE D'UN GROUPE DE GENES MODULAIRE DE POLYCETIDE SYNTHASE EN TANT QUE SQUELETTE
Abstract:
(EN) Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
(FR) Bibliothèques combinatoires de polycétides qui peuvent être obtenues par manipulation appropriée d'un groupe de gènes modulaire hôte de polycétide synthase tel que celui qui code la polycétide synthase pour l'érythromycine. Ladite bibliothèque est utile en tant que source de composés à activité pharmacologique. De plus, de nouveaux polycétides et antibiotiques sont préparés selon ce procédé.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)