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Machine translation
1. (WO1998049315) COMBINATORIAL POLYKETIDE LIBRARIES PRODUCED USING A MODULAR PKS GENE CLUSTER AS SCAFFOLD
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/049315    International Application No.:    PCT/US1998/008792
Publication Date: 05.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed:    09.11.1998    
IPC:
C07B 61/00 (2006.01), C07D 323/00 (2006.01), C07H 17/08 (2006.01), C12N 15/52 (2006.01)
Applicants: KOSAN BIOSCIENCES, INC. [US/US]; 1450 Rollins Road, Burlingame, CA 94010 (US).
THE BOARD OF REGENTS OF THE LELAND STANFORD JUNIOR UNIVERSITY [US/US]; Suite 350, 900 Welch Road, Palo Alto, CA 94304 (US)
Inventors: KHOSLA, Chaitan; (US).
ASHLEY, Gary; (US).
FU, Hong; (US).
KAO, Camilla, M.; (US).
MCDANIEL, Robert; (US)
Agent: MURASHIGE, Kate, H.; Morrison & Foerster LLP, 2000 Pennsylvania Avenue, N.W., Washington, DC 20006-1888 (US)
Priority Data:
08/846,247 30.04.1997 US
60/076,919 05.03.1998 US
Title (EN) COMBINATORIAL POLYKETIDE LIBRARIES PRODUCED USING A MODULAR PKS GENE CLUSTER AS SCAFFOLD
(FR) BIBLIOTHEQUES COMBINATOIRES DE POLYCETIDES PRODUITES A L'AIDE D'UN GROUPE DE GENES MODULAIRE DE POLYCETIDE SYNTHASE EN TANT QUE SQUELETTE
Abstract: front page image
(EN)Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
(FR)Bibliothèques combinatoires de polycétides qui peuvent être obtenues par manipulation appropriée d'un groupe de gènes modulaire hôte de polycétide synthase tel que celui qui code la polycétide synthase pour l'érythromycine. Ladite bibliothèque est utile en tant que source de composés à activité pharmacologique. De plus, de nouveaux polycétides et antibiotiques sont préparés selon ce procédé.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)