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1. (WO1998049311) RICIN-LIKE TOXIN VARIANTS FOR TREATMENT OF CANCER, VIRAL OR PARASITIC INFECTIONS

Pub. No.:    WO/1998/049311    International Application No.:    PCT/CA1998/000394
Publication Date: Fri Nov 06 00:59:59 CET 1998 International Filing Date: Fri May 01 01:59:59 CEST 1998
IPC: A61K 38/00
A61K 48/00
C07K 14/415
Applicants: DE NOVO ENZYME CORPORATION
BORGFORD, Thor
Inventors: BORGFORD, Thor
Title: RICIN-LIKE TOXIN VARIANTS FOR TREATMENT OF CANCER, VIRAL OR PARASITIC INFECTIONS
Abstract:
The present invention provides a protein having an A chain of a ricin-like toxin, a B chain of a ricin-like toxin and a heterologous linker amino acid sequence, linking the A and B chains. The linker sequence contains a cleavage recognition site for a disease specific protease such as a cancer, fungal, viral or parasitic protease. The invention also relates to a nucleic acid molecule encoding the protein and to expression vectors incorporating the nucleic acid molecule. Also provided is a method of inhibiting or destroying mammalian cancer cells, cells infected with a virus, a fungus, or parasite, or parasites utilizing the nucleic acid molecules and proteins of the invention and pharmaceutical compositions for treating human cancer, viral infection, fungal infection, or parasitic infection.