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1. (WO1998049308) NGF VARIANTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1998/049308    International Application No.:    PCT/US1998/008242
Publication Date: 05.11.1998 International Filing Date: 23.04.1998
Chapter 2 Demand Filed:    23.09.1998    
IPC:
A61K 38/00 (2006.01), C07K 14/48 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way, South San Francisco, CA 94080-4990 (US)
Inventors: PRESTA, Leonard, G.; (US).
URFER, Roman; (CH).
WINSLOW, John, W.; (US)
Agent: TORCHIA, Timothy, E.; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080-4990 (US).
KIDDLE, Simon; Mewburn Ellis, York House, 23 Kingsway, London WC2B 6HP (GB)
Priority Data:
08/845,541 25.04.1997 US
08/841,045 29.04.1997 US
Title (EN) NGF VARIANTS
(FR) VARIANTS DU FACTEUR DE CROISSANCE DU TISSU NERVEUX (FCN)
Abstract: front page image
(EN)NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.
(FR)L'invention a trait à des variants du FCN dotés d'une activité de fixation du récepteur tyrosine kinase-C (trkC) et d'une activité de déclenchement de signal trkC. Ces variants peuvent, éventuellement, être dotés d'une activité de fixation du trkA ou du trkB et d'une activité de déclenchement de signal. Les variants de l'invention se révèlent efficaces en matière de thérapie de troubles neuronaux. Cette invention concerne également des acides nucléiques et des vecteurs d'expression codant les neurotrophines du variant du FCN.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW.
African Regional Intellectual Property Organization (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)