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1. (WO1998049300) TRUNCATED VEGF-RELATED PROTEINS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/049300 International Application No.: PCT/US1998/007801
Publication Date: 05.11.1998 International Filing Date: 20.04.1998
Chapter 2 Demand Filed: 25.11.1998
IPC:
A61K 38/00 (2006.01) ,C07K 14/52 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
Applicants:
COLLATERAL THERAPEUTICS [US/US]; Suite 110 9360 Towne Centre Drive San Diego, CA 92121, US
Inventors:
BOHLEN, Peter; US
Agent:
SILVERSTEIN, Sheryl, R.; Lyon & Lyon LLP Suite 4700 633 West Fifth Street Los Angeles, CA 90071-2066, US
VIERING JENTSCHURA & PARTNER; Steiinsdorfstr. 6 D-80538 Munich, DE
Priority Data:
08/842,98425.04.1997US
Title (EN) TRUNCATED VEGF-RELATED PROTEINS
(FR) FORMES TRONQUEES DE PROTEINES APPARENTEES AU FACTEUR VEGF
Abstract:
(EN) The present invention provides novel truncated forms of vascular endothelial growth factor-related proteins (VRPs or VRPs) which are useful for the stimulation of angiogenesis $i(in vitro) and $i(in vivo). The invention also provides nucleic acids encoding such novel truncated VRPs and methods of producing truncated VRPs. Pharmaceutical compositions comprising truncated VRPs and methods of gene therapy using the nucleic acids which code for truncated VRPs may be useful for the treatment of heart disease and for wound healing.
(FR) Cette invention se rapporte à de nouvelles formes tronquées de protéines apparentées au facteur de croissance endothéliale vasculaire (VRP) qui servent à stimuler l'engiogenèse $i(in vitro) et $i(in vivo). Cette invention se rapporte également à des acides nucléiques codant ces nouvelles protéines VRP tronquées et à des procédés pour produire ces protéines VRP tronquées. Des compositions pharmaceutiques contenant ces protéines VRP tronquées et des procédés de thérapie génétique utilisant les acides nucléiques qui codent ces protéines VRP tronquées peuvent servir dans le traitement des maladies cardiaques et pour la cicatrisation des plaies.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
KR1020010020259SG68721IL132537EP0977854JP2001524828 CN1260835
CN1680442CA2287538EA199900861NZ500530NZ514872AU1998072502
AU2002300742