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1. (WO1998049297) NEURONAL MORT1 ISOFORMS

Pub. No.:    WO/1998/049297    International Application No.:    PCT/US1998/007439
Publication Date: Fri Nov 06 00:59:59 CET 1998 International Filing Date: Wed Apr 15 01:59:59 CEST 1998
IPC: C07K 14/715
Applicants: AMERICAN HOME PRODUCTS CORPORATION
Inventors: BINGHAM, Brendan, William
YOUNG, Kathleen, H.
WOOD, Andrew, Timothy
BIRSAN, Camelia
Title: NEURONAL MORT1 ISOFORMS
Abstract:
A MORT1 gene initially cloned from HeLa cells and identified as a member of the receptor mediated apoptotic pathway, is expressed in the human neuronal cell line, NTERA2. Isolation of the MORT1 from this cell line revealed a transcript isoform that differed from the known MORT1 sequence by a deletion of 21 base pairs (bp 172-192 of the coding sequence). Cloning of MORT1 from adult human brain revealed two isoforms, one similarly deleted for bp 172-192, the other with a basepair substitution, A for G at position 173. Assessment of MORT1 function in a yeast two hybrid system indicates that the deleted and intact forms of MORT1 differ in their capacity to interact with other members of the apoptotic pathway.