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1. (WO1998049296) HUMAN CERBERUS PROTEIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1998/049296 International Application No.: PCT/US1998/006324
Publication Date: 05.11.1998 International Filing Date: 31.03.1998
Chapter 2 Demand Filed: 10.11.1998
IPC:
A61K 38/00 (2006.01) ,C07K 14/475 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
475
Growth factors; Growth regulators
Applicants:
REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road Tarrytown, NY 10591-6707, US (AllExceptUS)
VALENZUELA, David, M. [CL/US]; US (UsOnly)
ROJAS, Eduardo, A. [CL/US]; US (UsOnly)
ECONOMIDES, Aris, N. [GR/US]; US (UsOnly)
STAHL, Neil, E. [US/US]; US (UsOnly)
Inventors:
VALENZUELA, David, M.; US
ROJAS, Eduardo, A.; US
ECONOMIDES, Aris, N.; US
STAHL, Neil, E.; US
Agent:
COBERT, Robert, J. ; Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown, NY 10591, US
GOLDIN, Douglas, Michael; J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX, GB
Priority Data:
60/044,42729.04.1997US
60/045,15730.04.1997US
Title (EN) HUMAN CERBERUS PROTEIN
(FR) PROTEINE CERBERUS HUMAINE
Abstract:
(EN) Human Cerberus proteins and related nucleic acids are provided. Included are proteins comprising a human cerberus domain having specific activity, particularly the ability to antagonize a bone morphogenic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.
(FR) L'invention concerne des protéines cerberus humaines et des acides nucléiques associés. On décrit des protéines ayant un domaine cerberus humain à activité spécifique, dont notamment une action antagoniste vis-à-vis d'une protéine osseuse morphogénique. Il est possible d'obtenir lesdites protéines par génie génétique à partir de cellules hôtes transformées avec les acides nucléiques de l'invention. L'invention concerne aussi des amorces et des sondes d'hybridation isolées, capables d'hybrider spécifiquement les gènes décrits, ainsi que des agents de liaison spécifiques et des procédés de fabrication et d'utilisation des compositions en question.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXPA/a/1999/009963IL132443EP0975752US6610510JP2001526535 CA2288373
NZ500577AU1998068736