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1. (WO1998049296) HUMAN CERBERUS PROTEIN

Pub. No.:    WO/1998/049296    International Application No.:    PCT/US1998/006324
Publication Date: Fri Nov 06 00:59:59 CET 1998 International Filing Date: Wed Apr 01 01:59:59 CEST 1998
IPC: A61K 38/00
C07K 14/475
Applicants: REGENERON PHARMACEUTICALS, INC.
VALENZUELA, David, M.
ROJAS, Eduardo, A.
ECONOMIDES, Aris, N.
STAHL, Neil, E.
Inventors: VALENZUELA, David, M.
ROJAS, Eduardo, A.
ECONOMIDES, Aris, N.
STAHL, Neil, E.
Title: HUMAN CERBERUS PROTEIN
Abstract:
Human Cerberus proteins and related nucleic acids are provided. Included are proteins comprising a human cerberus domain having specific activity, particularly the ability to antagonize a bone morphogenic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.