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1. (WO1998049292) POLYPEPTIDES ASSOCIATED WITH ACTIVATOR RECEPTORS AND THEIR BIOLOGICAL APPLICATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/049292 International Application No.: PCT/FR1998/000883
Publication Date: 05.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 11.11.1998
IPC:
A61K 38/00 (2006.01) ,A61K 48/00 (2006.01) ,C07K 14/705 (2006.01) ,C07K 16/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
Applicants:
VIVIER, Eric [FR/FR]; FR (UsOnly)
MORETTA, Alessandro [IT/IT]; IT (UsOnly)
OLCESE, Lucia [IT/IT]; IT (UsOnly)
VELY, Frédéric [FR/FR]; FR (UsOnly)
TOMASELLO, Elena [FR/FR]; FR (UsOnly)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR/FR]; 101, rue de Tolbiac F-75654 Paris Cedex 13, FR (AT, BE, CA, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, JP, LU, MC, NL, PT, SE)
Inventors:
VIVIER, Eric; FR
MORETTA, Alessandro; IT
OLCESE, Lucia; IT
VELY, Frédéric; FR
TOMASELLO, Elena; FR
Agent:
PEAUCELLE, Chantal ; Cabinet Armengaud Ainé 3, avenue Bugeaud F-75116 Paris, FR
ARMENGAUD, Alain ; Cabinet Armengaud Ainé 3, avenue Bugeaud F-75116 Paris, FR
Priority Data:
97/0541130.04.1997FR
98/0092728.01.1998FR
Title (EN) POLYPEPTIDES ASSOCIATED WITH ACTIVATOR RECEPTORS AND THEIR BIOLOGICAL APPLICATIONS
(FR) POLYPEPTIDES ASSOCIES A DES RECEPTEURS ACTIVATEURS ET LEURS APPLICATIONS BIOLOGIQUES
Abstract:
(EN) The invention concerns novel means for diagnosing, preventing, compensating, treating an abnormal or unwanted functioning of KAR receptors ($i(Killer cell Activatory Receptor)), counterparts of non-inhibiting KIR receptors ($i(Killer cell Inhibitory Receptors)) of the immunoglobulin or lectin type. The invention concerns, in particular, novel KARAP ($i(KAR-Associated Proteins)) polypeptides and their biological applications. A KARAP polypeptide is naturally associated with a KAR receptor, and in the absence of such a KARAP, said KAR receptor is naturally incapable of transducing an activating signal that can be detected. The application also concerns methods for obtaining or identifying such KARAP polypeptides.
(FR) La présente demande concerne de nouveaux moyens permettant de diagnostiquer, prévenir, pallier, traiter un fonctionnement anormal ou non désiré de récepteurs KAR (Killer cell Activatory Receptor), contreparties non inhibitrices de récepteurs KIR (Killer cell Inhibitory Receptors) de type immunoglobuline ou de type lectine. Elle est notamment relative à de nouveaux polypeptides KARAP (KAR-Associated Proteins) et à leurs applications biologiques. Un polypeptide KARAP, selon l'invention, est naturellement associé à un récepteur KAR, et en l'absence d'un tel KARAP, ledit récepteur KAR est naturellement incapable de transduire un signal activateur détectable. La présente demande vise également des méthodes d'obtention ou d'identification de tels polypeptides KARAP.
Designated States: CA, JP, US
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: French (FR)
Filing Language: French (FR)