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1. (WO1998049287) ANTISENSE OLIGONUCLEOTIDES SPECIFIC FOR THYMIDYLATE SYNTHASE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/049287 International Application No.: PCT/US1998/008722
Publication Date: 05.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 30.11.1998
IPC:
A61K 38/00 (2006.01) ,C12N 15/11 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
Applicants:
HYBRIDON, INC. [US/US]; 155 Fortune Boulevard Milford, MA 01757, US
Inventors:
SCHMITZ, John, C.; US
AGRAWAL, Sudhir; US
CHU, Edward; US
Agent:
GREENFEILD, Michael, S.; McDonnell Boehen Hulbert & Berghof 300 South Wacker Drive Suite 3200 Chicago, Illinois 60606, US
Priority Data:
60/045,23030.04.1997US
Title (EN) ANTISENSE OLIGONUCLEOTIDES SPECIFIC FOR THYMIDYLATE SYNTHASE
(FR) OLIGONUCLEOTIDES ANTISENS SPECIFIQUES D'UNE THYMIDYLATE SYNTHASE
Abstract:
(EN) The present invention discloses synthetic oligonucleotides complementary to thymidylate synthase and methods of downregulating at least a portion of thymidylate synthase mRNA translation or protein expression in a malignant cell and of preventing or overcoming resistance to thymidylate synthase inhibitor compounds in a malignant cell using such oligonucleotides. Also disclosed is a therapeutic composition and a method of treating malignant tumor growth in a mammal utilizing such a composition.
(FR) La présente invention concerne des oligonucléotides complémentaires d'une thymidylate synthase et des procédés de régulation négative d'au moins une partie d'une traduction d'ARNm ou d'une expression de protéine de thymidylate synthase, dans une cellule maligne. L'invention concerne également des procédés permettant d'empêcher ou de vaincre une résistance aux composés inhibiteurs de thymidylate synthase, dans une cellule maligne utilisant lesdits oligonucléotides. L'invention concerne, en outre, une composition et un procédé de traitement de croissance d'une tumeur maligne chez des mammifères, au moyen de ladite composition.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)