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1. (WO1998049286) DIRECTED EVOLUTION OF ENZYMES AND ANTIBODIES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1998/049286 International Application No.: PCT/US1998/008714
Publication Date: 05.11.1998 International Filing Date: 30.04.1998
Chapter 2 Demand Filed: 01.12.1998
IPC:
C12N 15/10 (2006.01)
Applicants: IVERSON, Brent[US/US]; US (UsOnly)
GEORGIOU, George[US/US]; US (UsOnly)
CHEN, Gang[CN/US]; US (UsOnly)
OLSEN, Mark, J.[US/US]; US (UsOnly)
DAUGHERTY, Patrick, S.[US/US]; US (UsOnly)
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM[US/US]; 201 West 7th Street Austin, TX 78701, US (AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CU, CY, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GH, GM, GN, GR, GW, HU, ID, IE, IL, IS, IT, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MC, MD, MG, MK, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, SN, SZ, TD, TG, TJ, TM, TR, TT, UA, UG, UZ, VN, YU, ZW)
Inventors: IVERSON, Brent; US
GEORGIOU, George; US
CHEN, Gang; US
OLSEN, Mark, J.; US
DAUGHERTY, Patrick, S.; US
Agent: MCMILLIAN, Nabeela, R.; Arnold, White & Durkee P.O. Box 4433 Houston, TX 77210, US
Priority Data:
08/847,06301.05.1997US
Title (EN) DIRECTED EVOLUTION OF ENZYMES AND ANTIBODIES
(FR) EVOLUTION ORIENTEE D'ENZYMES ET D'ANTICORPS
Abstract:
(EN) The invention relates to methods of selecting proteins, out of large libraries, having desirable characteristics. Exemplified are methods of expressing enzymes and antibodies on the surface of host cells and selecting for desired activities. These methods have the advantage of speed and ease of operation when compared with current methods. They also provide, without additional cloning, a source of significant quantities of the protein of interest.
(FR) La présente invention concerne des procédés de sélection de protéines, dans de grandes bibliothèques présentant des caractéristiques désirables. Des procédés d'expression d'enzymes et d'anticorps sur la surface de cellules hôtes et de sélection d'activités désirées sont donnés à titre d'exemple. Ces procédés comparés aux procédés actuels présentent l'avantage d'une utilisation rapide et facile et sont une source de quantités importantes de la protéine considérée, sans clonage supplémentaire.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, GM, GW, HU, ID, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW
African Regional Intellectual Property Organization (ARIPO) (GH, GM, KE, LS, MW, SD, SZ, UG, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)